biostudies-literatureYao QRadiumhemmets ForskningsfonderChina Sponsorship CouncilCancerfondene1004505https://www.ebi.ac.uk/biostudies/studies/S-EPMC11706452biostudies-literatureUnknown21(12)<h4>Background</h4>Evidence on invasive cervical cancer prevention among older women is limited, especially with the introduction of human papillomavirus (HPV)-based screening and longer interval. We conducted a long-term follow-up of the first phase of a randomized healthcare policy trial in cervical screening, targeting women aged 56 to 61 years old, to investigate the effectiveness of primary HPV-based screening in preventing invasive cervical cancer (ICC) and the safety of extending screening interval.<h4>Methods and findings</h4>The randomized healthcare policy trial of primary HPV-based cervical screening targeted women residing in Stockholm-Gotland region during 2012 to 2016, aged 30 to 64 years. The trial aimed to investigate the detection rate of cervical intraepithelial neoplasiaPLoS medicineEvaluation of primary HPV-based cervical screening among older women: Long-term follow-up of a randomized healthcare policy trial in Sweden.PMC1170645223417220220616001021 1690 PjDillner JElfstrom KMYao QWang JStrander BSundstrom KfalseEvaluation of primary HPV-based cervical screening among older women: Long-term follow-up of a randomized healthcare policy trial in Sweden.<h4>Background</h4>Evidence on invasive cervical cancer prevention among older women is limited, especially with the introduction of human papillomavirus (HPV)-based screening and longer interval. We conducted a long-term follow-up of the first phase of a randomized healthcare policy trial in cervical screening, targeting women aged 56 to 61 years old, to investigate the effectiveness of primary HPV-based screening in preventing invasive cervical cancer (ICC) and the safety of extending screening interval.<h4>Methods and findings</h4>The randomized healthcare policy trial of primary HPV-based cervical screening targeted women residing in Stockholm-Gotland region during 2012 to 2016, aged 30 to 64 years. The trial aimed to investigate the detection rate of cervical intraepithelial neoplasia2024-01-01T00:00:00Z2024 Dec2026-06-01T15:01:22.141Z2025-04-04T21:49:18.708ZS-EPMC117064523970031310.1371/journal.pmed.1004505