{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Ji M"],"pubmed_abstract":["<h4>Background and aims</h4>Pyrrolizidine alkaloids (PAs), widely distributed in plants, are known to induce liver failure. Hepatic platelet accumulation has been reported during the progression of PA-induced liver injury (PA-ILI). This study aimed to investigate the mechanisms underlying platelet accumulation in PA-ILI.<h4>Methods</h4>Cases of PA-ILI, non-PA-ILI, and control subjects were collected from patients hospitalized at Zhongshan Hospital, Fudan University (Shanghai, China) between 2012 and 2019. A mouse model of PA-ILI was established using monocrotaline administration. Liver RNA sequencing was performed, and gene interactions were analyzed using the Search Tool for the Retrieval of Interacting Genes/Proteins online database. Low-molecular-weight heparin and recombinant a disinte"],"journal":["Journal of clinical and translational hepatology"],"pagination":["25-34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11712092"],"repository":["biostudies-literature"],"pubmed_title":["ADAMTS13 Improves Hepatic Platelet Accumulation in Pyrrolizidine Alkaloids-induced Liver Injury."],"pmcid":["PMC11712092"],"pubmed_authors":["Li D","Ren J","Jiang H","Ma Y","Chen Y","Zeng X","Gao H","Chen S","Ji M"],"additional_accession":[]},"is_claimable":false,"name":"ADAMTS13 Improves Hepatic Platelet Accumulation in Pyrrolizidine Alkaloids-induced Liver Injury.","description":"<h4>Background and aims</h4>Pyrrolizidine alkaloids (PAs), widely distributed in plants, are known to induce liver failure. Hepatic platelet accumulation has been reported during the progression of PA-induced liver injury (PA-ILI). This study aimed to investigate the mechanisms underlying platelet accumulation in PA-ILI.<h4>Methods</h4>Cases of PA-ILI, non-PA-ILI, and control subjects were collected from patients hospitalized at Zhongshan Hospital, Fudan University (Shanghai, China) between 2012 and 2019. A mouse model of PA-ILI was established using monocrotaline administration. Liver RNA sequencing was performed, and gene interactions were analyzed using the Search Tool for the Retrieval of Interacting Genes/Proteins online database. Low-molecular-weight heparin and recombinant a disinte","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-07-15T08:50:12.839Z","creation":"2026-07-03T03:10:32.041Z"},"accession":"S-EPMC11712092","cross_references":{"pubmed":["39801786"],"doi":["10.14218/JCTH.2024.00233"]}}