{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pepin AS"],"funding":["Canadian Institutes of Health Research","CIHR"],"pagination":["e83288"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11717366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Paternal obesity has been implicated in adult-onset metabolic disease in offspring. However, the molecular mechanisms driving these paternal effects and the developmental processes involved remain poorly understood. One underexplored possibility is the role of paternally induced effects on placenta development and function. To address this, we investigated paternal high-fat diet-induced obesity in relation to sperm histone H3 lysine 4 tri-methylation signatures, the placenta transcriptome, and cellular composition. C57BL6/J male mice were fed either a control or high-fat diet for 10 weeks beginning at 6 weeks of age. Males were timed-mated with control-fed C57BL6/J females to generate pregnancies, followed by collection of sperm, and placentas at embryonic day (E)14.5. Chromatin immunoprec"],"journal":["eLife"],"pubmed_title":["Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition."],"pmcid":["PMC11717366"],"funding_grant_id":["175293","350129","146333","358654"],"pubmed_authors":["Sloboda DM","Dumeaux V","Jazwiec PA","Kimmins S","Pepin AS"],"additional_accession":[]},"is_claimable":false,"name":"Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition.","description":"Paternal obesity has been implicated in adult-onset metabolic disease in offspring. However, the molecular mechanisms driving these paternal effects and the developmental processes involved remain poorly understood. One underexplored possibility is the role of paternally induced effects on placenta development and function. To address this, we investigated paternal high-fat diet-induced obesity in relation to sperm histone H3 lysine 4 tri-methylation signatures, the placenta transcriptome, and cellular composition. C57BL6/J male mice were fed either a control or high-fat diet for 10 weeks beginning at 6 weeks of age. Males were timed-mated with control-fed C57BL6/J females to generate pregnancies, followed by collection of sperm, and placentas at embryonic day (E)14.5. Chromatin immunoprec","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-15T08:45:09.37Z","creation":"2026-07-01T03:12:31.888Z"},"accession":"S-EPMC11717366","cross_references":{"pubmed":["39612469"],"doi":["10.7554/eLife.83288"]}}