{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martinez-Lopez R"],"funding":["Spanish Ministry of Science and Innovation/ State Research Agency 10.13039/501100011033"],"pagination":["244"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11720215"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["Extracellular vesicles (EVs) from <i>Candida albicans</i> can elicit immune responses, positioning them as promising acellular vaccine candidates. We characterized EVs from an avirulent <i>C. albicans</i> cell wall mutant (<i>ecm33</i>Δ) and evaluated their protective potential against invasive candidiasis. EVs from the yeast (YEVs) and hyphal (HEVs) forms of the SC5314 wild-type strain were also tested, yielding high survival rates with SC5314 YEV (91%) and <i>ecm33</i> YEV immunization (64%). Surprisingly, HEV immunization showed a dual effect, resulting in 36% protection but also causing premature death in some mice. Proteomic analyses revealed distinct profiles among the top 100 proteins in the different EVs, which may explain these effects: a shared core of 50 immunogenic proteins suc"],"journal":["International journal of molecular sciences"],"pubmed_title":["From High Protection to Lethal Effect: Diverse Outcomes of Immunization Against Invasive Candidiasis with Different &lt;i&gt;Candida albicans&lt;/i&gt; Extracellular Vesicles."],"pmcid":["PMC11720215"],"funding_grant_id":["PID2021-124062NB-I00"],"pubmed_authors":["Molero G","Gil C","Cabeza MS","Martinez-Lopez R","Castejon G","Hernaez ML","Parra-Giraldo CM","Monteoliva L","Garcia-Duran C","Clemente LF"],"additional_accession":[]},"is_claimable":false,"name":"From High Protection to Lethal Effect: Diverse Outcomes of Immunization Against Invasive Candidiasis with Different &lt;i&gt;Candida albicans&lt;/i&gt; Extracellular Vesicles.","description":"Extracellular vesicles (EVs) from <i>Candida albicans</i> can elicit immune responses, positioning them as promising acellular vaccine candidates. We characterized EVs from an avirulent <i>C. albicans</i> cell wall mutant (<i>ecm33</i>Δ) and evaluated their protective potential against invasive candidiasis. EVs from the yeast (YEVs) and hyphal (HEVs) forms of the SC5314 wild-type strain were also tested, yielding high survival rates with SC5314 YEV (91%) and <i>ecm33</i> YEV immunization (64%). Surprisingly, HEV immunization showed a dual effect, resulting in 36% protection but also causing premature death in some mice. Proteomic analyses revealed distinct profiles among the top 100 proteins in the different EVs, which may explain these effects: a shared core of 50 immunogenic proteins suc","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-04-08T15:32:33.471Z","creation":"2026-04-08T05:00:10.843Z"},"accession":"S-EPMC11720215","cross_references":{"pubmed":["39796100"],"doi":["10.3390/ijms26010244"]}}