{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Yu J"],"funding":["NICHD NIH HHS"],"pubmed_abstract":["Zika virus (ZIKV) infection can lead to a variety of clinical outcomes, including severe congenital abnormalities. The phosphatidylserine (PS) receptors AXL and TIM-1 are recognized as critical entry factors for ZIKV <i>in vitro</i>. However, it remains unclear if and how ZIKV regulates these receptors during infection. In this study, we investigated AXL and TIM-1 expression in human alveolar basal epithelial A549 cells, glioblastoma U87 cells, and embryonic stem cells-derived trophoblast following ZIKV infection. We found that both the Asian strain FSS13025 and the African strain MR766 of ZIKV downregulate AXL, with a milder effect on TIM-1. We identified several ZIKV proteins, notably envelope (E), NS2A, NS3, and NS4B, that contribute to this downregulation. Notably, treatment with lysos"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.12.31.630961"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11722360"],"repository":["biostudies-literature"],"pubmed_title":["Autophagy-Mediated Downregulation of AXL and TIM-1 Promotes Sustained Zika Virus Infection."],"pmcid":["PMC11722360"],"funding_grant_id":["R01 HD094937"],"pubmed_authors":["Roberts RM","Sheridan MA","Ezashi T","Yu J","Zheng YM","Liu SL"],"additional_accession":[]},"is_claimable":false,"name":"Autophagy-Mediated Downregulation of AXL and TIM-1 Promotes Sustained Zika Virus Infection.","description":"Zika virus (ZIKV) infection can lead to a variety of clinical outcomes, including severe congenital abnormalities. The phosphatidylserine (PS) receptors AXL and TIM-1 are recognized as critical entry factors for ZIKV <i>in vitro</i>. However, it remains unclear if and how ZIKV regulates these receptors during infection. In this study, we investigated AXL and TIM-1 expression in human alveolar basal epithelial A549 cells, glioblastoma U87 cells, and embryonic stem cells-derived trophoblast following ZIKV infection. We found that both the Asian strain FSS13025 and the African strain MR766 of ZIKV downregulate AXL, with a milder effect on TIM-1. We identified several ZIKV proteins, notably envelope (E), NS2A, NS3, and NS4B, that contribute to this downregulation. Notably, treatment with lysos","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-04-19T03:30:09.993Z","creation":"2025-04-07T07:52:20.345Z"},"accession":"S-EPMC11722360","cross_references":{"pubmed":["39803534"],"doi":["10.1101/2024.12.31.630961"]}}