{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["102(27)"],"submitter":["Ishii H"],"pubmed_abstract":["We report the identification and characterization of a potent regulator of genomic integrity, mouse and human FRAG1 gene, a conserved homolog of replication factor C large subunit that is homologous to the alternative replication factor C subunits Elg1, Ctf18/Chl12, and Rad24 of budding yeast. FRAG1 was identified in a search for key caretaker genes involved in the regulation of genomic stability under conditions of replicative stress. In response to stress, Atr participates in the down-regulation of FRAG1 expression, leading to the induction of apoptosis through the release of Rad9 from damaged chromatin during the S phase of the cell cycle, allowing Rad9-Bcl2 association and induction of proapoptotic Bax protein. We propose that the Frag1 signal pathway, by linking replication stress sur"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["9655-60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1172282"],"repository":["biostudies-literature"],"pubmed_title":["Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis."],"pmcid":["PMC1172282"],"pubmed_authors":["Mori M","Inageta T","Ozawa K","Saito T","Furukawa Y","Sasaki H","Croce CM","Ishii H","Mimori K","Huebner K","Isobe M"],"additional_accession":[]},"is_claimable":false,"name":"Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.","description":"We report the identification and characterization of a potent regulator of genomic integrity, mouse and human FRAG1 gene, a conserved homolog of replication factor C large subunit that is homologous to the alternative replication factor C subunits Elg1, Ctf18/Chl12, and Rad24 of budding yeast. FRAG1 was identified in a search for key caretaker genes involved in the regulation of genomic stability under conditions of replicative stress. In response to stress, Atr participates in the down-regulation of FRAG1 expression, leading to the induction of apoptosis through the release of Rad9 from damaged chromatin during the S phase of the cell cycle, allowing Rad9-Bcl2 association and induction of proapoptotic Bax protein. We propose that the Frag1 signal pathway, by linking replication stress sur","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Jul","modification":"2026-05-30T08:47:10.73Z","creation":"2019-03-27T01:09:06Z"},"accession":"S-EPMC1172282","cross_references":{"pubmed":["15983387"],"doi":["10.1073/pnas.0504222102"]}}