biostudies-literatureUnknown33(2)Mercadante V<h4>Purpose</h4>This systematic review aimed to assess the updated literature for the prevention of salivary gland hypofunction and xerostomia induced by non-surgical cancer therapies.<h4>Methods</h4>Electronic databases of MEDLINE/PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials (RCT) that investigated interventions to prevent salivary gland hypofunction and/or xerostomia. Literature search began from the 2010 systematic review publications from the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) up to February 2024. Two independent reviewers extracted information regarding study design, study population, cancer treatment modality, interventions, outcome measures, methods, results, risk of bias (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer87https://www.ebi.ac.uk/biostudies/studies/S-EPMC11723892biostudies-literatureA systematic review of salivary gland hypofunction and/or xerostomia induced by non-surgical cancer therapies: prevention strategies.PMC11723892Mercadante VClark HNapenas JJElad SKurup SWu JAndabak-Rogulj ASaunders DPPeterson DEAbdalla-Aslan RJaguar GCVissink AHovan AVan Leeuwen SSmith DKJensen SBBrennan MTGueiros LALynggaard CDFregnani ERLaheij AMGAfalseA systematic review of salivary gland hypofunction and/or xerostomia induced by non-surgical cancer therapies: prevention strategies.<h4>Purpose</h4>This systematic review aimed to assess the updated literature for the prevention of salivary gland hypofunction and xerostomia induced by non-surgical cancer therapies.<h4>Methods</h4>Electronic databases of MEDLINE/PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials (RCT) that investigated interventions to prevent salivary gland hypofunction and/or xerostomia. Literature search began from the 2010 systematic review publications from the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) up to February 2024. Two independent reviewers extracted information regarding study design, study population, cancer treatment modality, interventions, outcome measures, methods, results, risk of bias (2025-01-01T00:00:00Z2025 Jan2026-06-02T07:15:24.068Z2025-04-07T05:01:52.883ZS-EPMC117238923979225610.1007/s00520-024-09113-x