{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kassem AF"],"funding":["Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University"],"pagination":["1033-1048"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11726445"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["A novel molecular design based on a quinazolinone scaffold was developed <i>via</i> the attachment of aryl alkanesulfonates to the quinazolinone core through a thioacetohydrazide azomethine linker, leading to a new series of quinazolinone-alkanesulfonates 5a-r. The antimicrobial properties of the newly synthesized quinazolinone derivatives 5a-r were investigated to examine their bactericidal and fungicidal activities against bacterial pathogens like <i>Bacillus subtilis</i>, <i>Staphylococcus aureus</i> (Gram-positive), <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumonia</i>, <i>Sallmonella Typhimurium</i> (Gram-negative), in addition to <i>Candida albicans</i> (unicellular fungal). The tested compounds demonstrated reasonable bactericidal activities compared to standard drugs. Notably,"],"journal":["RSC advances"],"pubmed_title":["New quinazolone-sulfonate conjugates with an acetohydrazide linker as potential antimicrobial agents: design, synthesis and molecular docking simulations."],"pmcid":["PMC11726445"],"funding_grant_id":["PNURSP2024R89"],"pubmed_authors":["Omar MA","Temirak A","Ragab SS","Altwaijry NA","Abdelraof M","Srour AM","Kassem AF","Saleh A"],"additional_accession":[]},"is_claimable":false,"name":"New quinazolone-sulfonate conjugates with an acetohydrazide linker as potential antimicrobial agents: design, synthesis and molecular docking simulations.","description":"A novel molecular design based on a quinazolinone scaffold was developed <i>via</i> the attachment of aryl alkanesulfonates to the quinazolinone core through a thioacetohydrazide azomethine linker, leading to a new series of quinazolinone-alkanesulfonates 5a-r. The antimicrobial properties of the newly synthesized quinazolinone derivatives 5a-r were investigated to examine their bactericidal and fungicidal activities against bacterial pathogens like <i>Bacillus subtilis</i>, <i>Staphylococcus aureus</i> (Gram-positive), <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumonia</i>, <i>Sallmonella Typhimurium</i> (Gram-negative), in addition to <i>Candida albicans</i> (unicellular fungal). The tested compounds demonstrated reasonable bactericidal activities compared to standard drugs. Notably,","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-02T07:05:08.305Z","creation":"2025-04-19T14:06:16.609Z"},"accession":"S-EPMC11726445","cross_references":{"pubmed":["39807202"],"doi":["10.1039/d4ra07563c"]}}