biostudies-literatureKassem AFDeanship of Scientific Research, Princess Nourah Bint Abdulrahman University1033-1048https://www.ebi.ac.uk/biostudies/studies/S-EPMC11726445biostudies-literatureUnknown15(2)A novel molecular design based on a quinazolinone scaffold was developed <i>via</i> the attachment of aryl alkanesulfonates to the quinazolinone core through a thioacetohydrazide azomethine linker, leading to a new series of quinazolinone-alkanesulfonates 5a-r. The antimicrobial properties of the newly synthesized quinazolinone derivatives 5a-r were investigated to examine their bactericidal and fungicidal activities against bacterial pathogens like <i>Bacillus subtilis</i>, <i>Staphylococcus aureus</i> (Gram-positive), <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumonia</i>, <i>Sallmonella Typhimurium</i> (Gram-negative), in addition to <i>Candida albicans</i> (unicellular fungal). The tested compounds demonstrated reasonable bactericidal activities compared to standard drugs. Notably,RSC advancesNew quinazolone-sulfonate conjugates with an acetohydrazide linker as potential antimicrobial agents: design, synthesis and molecular docking simulations.PMC11726445PNURSP2024R89Omar MATemirak ARagab SSAltwaijry NAAbdelraof MSrour AMKassem AFSaleh AfalseNew quinazolone-sulfonate conjugates with an acetohydrazide linker as potential antimicrobial agents: design, synthesis and molecular docking simulations.A novel molecular design based on a quinazolinone scaffold was developed <i>via</i> the attachment of aryl alkanesulfonates to the quinazolinone core through a thioacetohydrazide azomethine linker, leading to a new series of quinazolinone-alkanesulfonates 5a-r. The antimicrobial properties of the newly synthesized quinazolinone derivatives 5a-r were investigated to examine their bactericidal and fungicidal activities against bacterial pathogens like <i>Bacillus subtilis</i>, <i>Staphylococcus aureus</i> (Gram-positive), <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumonia</i>, <i>Sallmonella Typhimurium</i> (Gram-negative), in addition to <i>Candida albicans</i> (unicellular fungal). The tested compounds demonstrated reasonable bactericidal activities compared to standard drugs. Notably,2025-01-01T00:00:00Z2025 Jan2026-06-02T07:05:08.305Z2025-04-19T14:06:16.609ZS-EPMC117264453980720210.1039/d4ra07563c