biostudies-literatureLiu CMNIDDK NIH HHS00137-2024https://www.ebi.ac.uk/biostudies/studies/S-EPMC11726580biostudies-literatureUnknown11(1)<h4>Background</h4>Chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) are prevalent disease complications in people with cystic fibrosis. These understudied comorbidities significantly impact quality of life. The impact of highly effective modulator therapy (HEMT) in young children with cystic fibrosis (YCwCF) on these disease complications is unknown. This proposed study aims to characterise CRS and OD in YCwCF and assess the efficacy of HEMT in improving sinus and olfactory health in this young age group.<h4>Methods</h4>This six-centre, prospective, observational study will enrol 80 YCwCF aged 2-8 years. Patients are divided into two groups: those receiving HEMT and those not on HEMT based on clinical indication. Both groups undergo sinus magnetic resonance imaging, psychophysicERJ open researchThe impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol.PMC11726580P30 DK089507Hoffman LRFroh DLewis MMilla SSWoods JCSullivan JSSawatzky BDOde KLHeltshe SLGoss CHFischer JLTaylor-Cousar JLBeswick DMSim MSKramer ELNiedbalski PJZemanick ETMata JTrout ATMarkarian KKFain SBHumphries SMLiu CMLi DAfalseThe impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol.<h4>Background</h4>Chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) are prevalent disease complications in people with cystic fibrosis. These understudied comorbidities significantly impact quality of life. The impact of highly effective modulator therapy (HEMT) in young children with cystic fibrosis (YCwCF) on these disease complications is unknown. This proposed study aims to characterise CRS and OD in YCwCF and assess the efficacy of HEMT in improving sinus and olfactory health in this young age group.<h4>Methods</h4>This six-centre, prospective, observational study will enrol 80 YCwCF aged 2-8 years. Patients are divided into two groups: those receiving HEMT and those not on HEMT based on clinical indication. Both groups undergo sinus magnetic resonance imaging, psychophysic2025-01-01T00:00:00Z2025 Jan2026-07-15T11:11:55.028Z2026-07-05T03:08:24.46ZS-EPMC117265803981154810.1183/23120541.00137-2024