biostudies-literatureKadam LDepartment of EnergyNICHD NIH HHSNational Institute of Child Health and Human Development76-83https://www.ebi.ac.uk/biostudies/studies/S-EPMC11729490biostudies-literatureUnknown159<h4>Introduction</h4>The placenta uses lipids and other nutrients to support its own metabolism hence impacting the type and amount of these substrates available to the growing fetus. Maternal obesity and gestational diabetes (GDM) can disrupt placental lipid metabolism and thus lead to altered fetal growth contributing to adverse pregnancy outcomes and developmentally programing the offspring for disease in later life. Understanding obesity and GDM driven changes in placental lipid metabolism is thus important.<h4>Methods</h4>We collected maternal plasma and placental villous tissue following elective cesarean section at term from women who were lean (pre-pregnancy BMI 18.5-24.9), obese (BMI>30) or obese with type A2 GDM n = 8 each group (4 male and 4 female placentas). Fatty acid composiPlacentaSexual dimorphism in lipidomic changes in maternal blood and placenta associated with obesity and gestational diabetes: A discovery study.PMC11729490R01 HD095610DE-AC05-76RL01830Nicora CDBramer LMBurnum-Johnson KEMonroe MEMyatt LStratton KWang EKyle JEVelickovic MKadam LfalseSexual dimorphism in lipidomic changes in maternal blood and placenta associated with obesity and gestational diabetes: A discovery study.<h4>Introduction</h4>The placenta uses lipids and other nutrients to support its own metabolism hence impacting the type and amount of these substrates available to the growing fetus. Maternal obesity and gestational diabetes (GDM) can disrupt placental lipid metabolism and thus lead to altered fetal growth contributing to adverse pregnancy outcomes and developmentally programing the offspring for disease in later life. Understanding obesity and GDM driven changes in placental lipid metabolism is thus important.<h4>Methods</h4>We collected maternal plasma and placental villous tissue following elective cesarean section at term from women who were lean (pre-pregnancy BMI 18.5-24.9), obese (BMI>30) or obese with type A2 GDM n = 8 each group (4 male and 4 female placentas). Fatty acid composi2025-01-01T00:00:00Z2025 Jan2026-06-06T19:57:54.216Z2026-06-04T03:11:59.064ZS-EPMC117294903966211010.1016/j.placenta.2024.12.002