{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(4)"],"submitter":["Deng Z"],"pubmed_abstract":["<i>Rationale:</i> Next-generation wound dressings with multiple biological functions hold promise for addressing the complications and pain associated with burn wounds. <i>Methods:</i> A hydrogel wound dressing loaded with a pain-relieving drug was developed for treating infected burn wounds. Polyvinyl alcohol chemically grafted with gallic acid (PVA-GA), sodium alginate chemically grafted with 3-aminobenzeneboronic acid (SA-PBA), Zn<sup>2+</sup>, and chitosan-coated borneol nanoparticles with anti-inflammatory and pain-relieving activities were combined to afford a nanoparticle-loaded hydrogel with a PVA-GA/Zn<sup>2+</sup>/SA-PBA network crosslinked via multiple physicochemical interactions. <i>Results:</i> The developed hydrogel demonstrated adhesiveness, self-healing, shape adaptability"],"journal":["Theranostics"],"pagination":["1439-1455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11729554"],"repository":["biostudies-literature"],"pubmed_title":["Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing."],"pmcid":["PMC11729554"],"pubmed_authors":["Yang G","Shen L","Guo Y","Deng Z","Wang W","Wang X","Wang Y","Guo B","Song J","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing.","description":"<i>Rationale:</i> Next-generation wound dressings with multiple biological functions hold promise for addressing the complications and pain associated with burn wounds. <i>Methods:</i> A hydrogel wound dressing loaded with a pain-relieving drug was developed for treating infected burn wounds. Polyvinyl alcohol chemically grafted with gallic acid (PVA-GA), sodium alginate chemically grafted with 3-aminobenzeneboronic acid (SA-PBA), Zn<sup>2+</sup>, and chitosan-coated borneol nanoparticles with anti-inflammatory and pain-relieving activities were combined to afford a nanoparticle-loaded hydrogel with a PVA-GA/Zn<sup>2+</sup>/SA-PBA network crosslinked via multiple physicochemical interactions. <i>Results:</i> The developed hydrogel demonstrated adhesiveness, self-healing, shape adaptability","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-18T12:48:24.957Z","creation":"2025-04-06T22:10:03.779Z"},"accession":"S-EPMC11729554","cross_references":{"pubmed":["39816695"],"doi":["10.7150/thno.102569"]}}