{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Lee YH"],"pubmed_abstract":["<h4>Objectives</h4>This study examined the correlation between circulating receptor activator for nuclear factor-κB ligand (RANKL) levels and rheumatoid arthritis (RA), and investigated the association between polymorphisms in the RANKL gene and susceptibility to RA.<h4>Method</h4>We searched the Medline, Embase, and Cochrane databases for relevant publications up to September 2024. A meta-analysis was conducted to assess serum/plasma RANKL levels in patients with RA and controls, and to explore the relationship between RANKL rs9533156 and rs2277438 polymorphisms and RA susceptibility.<h4>Results</h4>Ten studies encompassing 1,682 RA patients and 1,288 controls were analyzed. RANKL levels were significantly higher in RA patients compared to controls (SMD = 0.665, 95% CI = 0.290-1.040, P = "],"journal":["PloS one"],"pagination":["e0317517"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11729962"],"repository":["biostudies-literature"],"pubmed_title":["Associations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis."],"pmcid":["PMC11729962"],"pubmed_authors":["Song GG","Lee YH"],"additional_accession":[]},"is_claimable":false,"name":"Associations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis.","description":"<h4>Objectives</h4>This study examined the correlation between circulating receptor activator for nuclear factor-κB ligand (RANKL) levels and rheumatoid arthritis (RA), and investigated the association between polymorphisms in the RANKL gene and susceptibility to RA.<h4>Method</h4>We searched the Medline, Embase, and Cochrane databases for relevant publications up to September 2024. A meta-analysis was conducted to assess serum/plasma RANKL levels in patients with RA and controls, and to explore the relationship between RANKL rs9533156 and rs2277438 polymorphisms and RA susceptibility.<h4>Results</h4>Ten studies encompassing 1,682 RA patients and 1,288 controls were analyzed. RANKL levels were significantly higher in RA patients compared to controls (SMD = 0.665, 95% CI = 0.290-1.040, P = ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-08T19:48:54.646Z","creation":"2025-04-06T01:14:52.647Z"},"accession":"S-EPMC11729962","cross_references":{"pubmed":["39804865"],"doi":["10.1371/journal.pone.0317517"]}}