biostudies-literatureUnknown20(1)Lee YH<h4>Objectives</h4>This study examined the correlation between circulating receptor activator for nuclear factor-κB ligand (RANKL) levels and rheumatoid arthritis (RA), and investigated the association between polymorphisms in the RANKL gene and susceptibility to RA.<h4>Method</h4>We searched the Medline, Embase, and Cochrane databases for relevant publications up to September 2024. A meta-analysis was conducted to assess serum/plasma RANKL levels in patients with RA and controls, and to explore the relationship between RANKL rs9533156 and rs2277438 polymorphisms and RA susceptibility.<h4>Results</h4>Ten studies encompassing 1,682 RA patients and 1,288 controls were analyzed. RANKL levels were significantly higher in RA patients compared to controls (SMD = 0.665, 95% CI = 0.290-1.040, P = PloS onee0317517https://www.ebi.ac.uk/biostudies/studies/S-EPMC11729962biostudies-literatureAssociations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis.PMC11729962Song GGLee YHfalseAssociations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis.<h4>Objectives</h4>This study examined the correlation between circulating receptor activator for nuclear factor-κB ligand (RANKL) levels and rheumatoid arthritis (RA), and investigated the association between polymorphisms in the RANKL gene and susceptibility to RA.<h4>Method</h4>We searched the Medline, Embase, and Cochrane databases for relevant publications up to September 2024. A meta-analysis was conducted to assess serum/plasma RANKL levels in patients with RA and controls, and to explore the relationship between RANKL rs9533156 and rs2277438 polymorphisms and RA susceptibility.<h4>Results</h4>Ten studies encompassing 1,682 RA patients and 1,288 controls were analyzed. RANKL levels were significantly higher in RA patients compared to controls (SMD = 0.665, 95% CI = 0.290-1.040, P = 2025-01-01T00:00:00Z20252026-04-08T19:48:54.646Z2025-04-06T01:14:52.647ZS-EPMC117299623980486510.1371/journal.pone.0317517