{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["44(2)"],"submitter":["Nataprawira HM"],"pubmed_abstract":["<h4>Background</h4>Data on childhood and adolescent multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) in Indonesia are lacking. We aimed to assess clinical features, adverse events (AEs) and treatment outcomes of childhood and adolescent MDR/RR-TB.<h4>Methods</h4>A retrospective cohort study was performed in children and adolescents <18 years old treated for MDR/RR-TB at Hasan Sadikin General Hospital in Bandung, Indonesia, between June 2016 and March 2024. Multivariable logistic regression analyses were used to calculate adjusted odds ratios (aOR) for predictors of all-cause mortality.<h4>Results</h4>Among 84 included patients, 69 (82%) were adolescents 10-17 years of age, 54 (64%) were female, 54 (64%) were malnourished and 55 (65%) had culture-confirmed disease. Among 69 (82%) pat"],"journal":["The Pediatric infectious disease journal"],"pagination":["143-150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11731024"],"repository":["biostudies-literature"],"pubmed_title":["Clinical Features, Adverse Events and Treatment Outcomes of Multidrug/Rifampicin-resistant Tuberculosis in Children and Adolescents: An Eight-year Retrospective Cohort Study in Bandung, Indonesia."],"pmcid":["PMC11731024"],"pubmed_authors":["Nataprawira HM","Ruslami R","Menzies D","Gafar F","Sari CA","Alffenaar JC","Marais BJ"],"additional_accession":[]},"is_claimable":false,"name":"Clinical Features, Adverse Events and Treatment Outcomes of Multidrug/Rifampicin-resistant Tuberculosis in Children and Adolescents: An Eight-year Retrospective Cohort Study in Bandung, Indonesia.","description":"<h4>Background</h4>Data on childhood and adolescent multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) in Indonesia are lacking. We aimed to assess clinical features, adverse events (AEs) and treatment outcomes of childhood and adolescent MDR/RR-TB.<h4>Methods</h4>A retrospective cohort study was performed in children and adolescents <18 years old treated for MDR/RR-TB at Hasan Sadikin General Hospital in Bandung, Indonesia, between June 2016 and March 2024. Multivariable logistic regression analyses were used to calculate adjusted odds ratios (aOR) for predictors of all-cause mortality.<h4>Results</h4>Among 84 included patients, 69 (82%) were adolescents 10-17 years of age, 54 (64%) were female, 54 (64%) were malnourished and 55 (65%) had culture-confirmed disease. Among 69 (82%) pat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-01T05:04:25.426Z","creation":"2025-04-06T01:17:21.605Z"},"accession":"S-EPMC11731024","cross_references":{"pubmed":["39312636"],"doi":["10.1097/INF.0000000000004539"]}}