biostudies-literatureSeraj FPakistan Academy of SciencesHigher Education Commision, Pakistan2609-2625https://www.ebi.ac.uk/biostudies/studies/S-EPMC11731353biostudies-literatureUnknown16(24)<b>Aim:</b> Quinoline scaffolds are serving as the core structure for numerous antifungal, analgesic, antipyretic, anti-inflammatory drugs as well as have also been investigated for their potential antidiabetic properties. Though further exploration is required in this area as the current antidiabetic agents, such as acarbose, miglitol and voglibose, are associated with several adverse side effects. In this context, arylated tetrahydrobenzo[<i>H</i>]quinoline-3-carbonitrile derivatives were designed and evaluated as potential antidiabetic agents.<b>Materials & methods:</b> A one-pot multicomponent reaction of 6-methoxy-1-tetralone with ethyl cyanoacetate, ammonium acetate and varying aldehydes yielded a range of new arylated tetrahydrobenzo[<i>h</i>]quinoline-3-carbonitrile molecules <b>1-Future medicinal chemistrySynthesis of arylated tetrahydrobenzo[&lt;i&gt;H&lt;/i&gt;]quinoline-3-carbonitrile derivatives as potential hits for treatment of diabetes.PMC11731353Project No. 111HEC Indigenous 5000 FellowshipTariq SSBaltas NNaz FOzil MKhan KMSeraj FTaha MSalar UUl-Haq ZfalseSynthesis of arylated tetrahydrobenzo[&lt;i&gt;H&lt;/i&gt;]quinoline-3-carbonitrile derivatives as potential hits for treatment of diabetes.<b>Aim:</b> Quinoline scaffolds are serving as the core structure for numerous antifungal, analgesic, antipyretic, anti-inflammatory drugs as well as have also been investigated for their potential antidiabetic properties. Though further exploration is required in this area as the current antidiabetic agents, such as acarbose, miglitol and voglibose, are associated with several adverse side effects. In this context, arylated tetrahydrobenzo[<i>H</i>]quinoline-3-carbonitrile derivatives were designed and evaluated as potential antidiabetic agents.<b>Materials & methods:</b> A one-pot multicomponent reaction of 6-methoxy-1-tetralone with ethyl cyanoacetate, ammonium acetate and varying aldehydes yielded a range of new arylated tetrahydrobenzo[<i>h</i>]quinoline-3-carbonitrile molecules <b>1-2024-01-01T00:00:00Z2024 Dec2026-05-18T03:19:20.032Z2026-05-18T03:13:01.993ZS-EPMC117313533953052610.1080/17568919.2024.2419359