biostudies-literatureUnknown11(1)Costa JV<h4>Background</h4>To determine the feasibility, acceptability, and preliminary efficacy of a 6-month tailored non-linear progressive physical activity intervention (PAI) for lymphoma patients undergoing chemotherapy.<h4>Methods</h4>Patients newly diagnosed with lymphoma (non-Hodgkin (NHL) or Hodgkin (HL)) were randomized into the PAI or healthy living intervention (HLI) control (2:1). Feasibility was assessed by examining accrual, adherence, and retention rates. Participants completed assessments of exercise capacity (VO₂ peak and 6-min walk distance (6MWD)), objective and self-reported levels of physical activity, MRI-derived cardiovascular functioning (Left Ventricular Ejection Fraction [LVEF], stroke volume, and cardiac output), and self-reported health-related and disease-sPilot and feasibility studies6https://www.ebi.ac.uk/biostudies/studies/S-EPMC11731389biostudies-literatureFeasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment.PMC11731389Hundley WGWolle BRFranco RLVaidya RD'Agostino RLucas ARWagner LSeegars MBVia JCosta JVMarshall ALeitzelar BNorton SBrubaker PHYazbeck VMihalko SLfalseFeasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment.<h4>Background</h4>To determine the feasibility, acceptability, and preliminary efficacy of a 6-month tailored non-linear progressive physical activity intervention (PAI) for lymphoma patients undergoing chemotherapy.<h4>Methods</h4>Patients newly diagnosed with lymphoma (non-Hodgkin (NHL) or Hodgkin (HL)) were randomized into the PAI or healthy living intervention (HLI) control (2:1). Feasibility was assessed by examining accrual, adherence, and retention rates. Participants completed assessments of exercise capacity (VO₂ peak and 6-min walk distance (6MWD)), objective and self-reported levels of physical activity, MRI-derived cardiovascular functioning (Left Ventricular Ejection Fraction [LVEF], stroke volume, and cardiac output), and self-reported health-related and disease-s2025-01-01T00:00:00Z2025 Jan2026-06-01T14:36:51.702Z2025-04-06T01:14:26.75ZS-EPMC117313893981028010.1186/s40814-024-01580-7