{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xue Y"],"funding":["National Administration of Traditional Chinese Medicine","Department of Education of Guizhou Province","Young Scientist Support Project of Guizhou Province","National Natural Science Foundation of China","Guizhou Provincial Science and Technology Plan Project","High-level Innovative Talents of Guizhou Province"],"pagination":["421-426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11731520"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(1)"],"pubmed_abstract":["In this work, coixalkyne A (<b>1</b>), a natural polynuclear calcium complex with a novel cross-shaped molecular architecture, was isolated from <i>Coix lacryma-jobi</i> L. along with the undescribed analogue coixalkyne B (<b>2</b>). Their structures were identified by means of NMR spectroscopy, ECD calculations, and single-crystal X-ray diffraction. It is noteworthy that the calcium ligands of <b>1</b> as well as compound <b>2</b> possess rare terminal alkynes and a <i>nor</i>-carbon sesquiterpene (C14) framework. The antihyperuricemic activity of <i>C. lacryma-jobi</i> and xanthine oxidase (XOD) inhibitory effects of <b>1</b>-<b>2</b> were elucidated by <i>in vivo</i> and <i>in vitro</i> assays, while the possible mechanism of action was suggested by molecular docking. Different from the"],"journal":["Organic letters"],"pubmed_title":["Discovery, Characterization, and Anti-XOD Activity of Calcium Metallophore from &lt;i&gt;Coix lacryma-jobi&lt;/i&gt;."],"pmcid":["PMC11731520"],"funding_grant_id":["GASTYESS202437","82260847","Qian Ke He Ji Chu-ZK [2023] Key Project 046","Qian Jiao Ji [2023] No. 069","Qian Ke He platform talents-GCC [2023] 047","Qian Ke He Ji Chu-ZK [2023] Yi Ban 430","zyyzdxk-2023185"],"pubmed_authors":["Feng TT","Song D","Liu SR","Wei X","Lei CW","Zhou Y","Shi H","Xue Y"],"additional_accession":[]},"is_claimable":false,"name":"Discovery, Characterization, and Anti-XOD Activity of Calcium Metallophore from &lt;i&gt;Coix lacryma-jobi&lt;/i&gt;.","description":"In this work, coixalkyne A (<b>1</b>), a natural polynuclear calcium complex with a novel cross-shaped molecular architecture, was isolated from <i>Coix lacryma-jobi</i> L. along with the undescribed analogue coixalkyne B (<b>2</b>). Their structures were identified by means of NMR spectroscopy, ECD calculations, and single-crystal X-ray diffraction. It is noteworthy that the calcium ligands of <b>1</b> as well as compound <b>2</b> possess rare terminal alkynes and a <i>nor</i>-carbon sesquiterpene (C14) framework. The antihyperuricemic activity of <i>C. lacryma-jobi</i> and xanthine oxidase (XOD) inhibitory effects of <b>1</b>-<b>2</b> were elucidated by <i>in vivo</i> and <i>in vitro</i> assays, while the possible mechanism of action was suggested by molecular docking. Different from the","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-06T05:48:37.148Z","creation":"2026-05-27T03:11:29.229Z"},"accession":"S-EPMC11731520","cross_references":{"pubmed":["39791234"],"doi":["10.1021/acs.orglett.4c04391"]}}