{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(1)"],"submitter":["Gaikwad KB"],"funding":["Wellcome Trust"],"pubmed_abstract":["<h4>Background</h4>Keratoconus is an etiologically complex, degenerative corneal disease that eventually leads to loss of corneal integrity. Cells in corneal epithelium and endothelium express various types of ion channels that play important roles in ocular pathology. This emphasizes the need of understanding alterations of ion channels in keratoconus.<h4>Method</h4>Differential gene expression analysis was performed to identify deregulated ion channels in keratoconus patients using transcriptomic data. Thereafter correlation analysis of ion channel expression was performed to obtain the changed correlation between ion channels' expression in keratoconus patients versus control samples. Moreover, Protein-protein interaction networks and a pathway map was constructed to identify cellular p"],"journal":["Eye (London, England)"],"pagination":["145-153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11733014"],"repository":["biostudies-literature"],"pubmed_title":["Computational approaches for identifications of altered ion channels in keratoconus."],"pmcid":["PMC11733014"],"pubmed_authors":["Gaikwad KB","Parthasarathi KTS","Gundimeda S","Padmanabhan P","Elchuri SV","Narayanan J","Babu JS","Pandey A","Sharma J"],"additional_accession":[]},"is_claimable":false,"name":"Computational approaches for identifications of altered ion channels in keratoconus.","description":"<h4>Background</h4>Keratoconus is an etiologically complex, degenerative corneal disease that eventually leads to loss of corneal integrity. Cells in corneal epithelium and endothelium express various types of ion channels that play important roles in ocular pathology. This emphasizes the need of understanding alterations of ion channels in keratoconus.<h4>Method</h4>Differential gene expression analysis was performed to identify deregulated ion channels in keratoconus patients using transcriptomic data. Thereafter correlation analysis of ion channel expression was performed to obtain the changed correlation between ion channels' expression in keratoconus patients versus control samples. Moreover, Protein-protein interaction networks and a pathway map was constructed to identify cellular p","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-01T08:59:55.635Z","creation":"2025-04-06T01:13:49.38Z"},"accession":"S-EPMC11733014","cross_references":{"pubmed":["39420106"],"doi":["10.1038/s41433-024-03395-5"]}}