biostudies-literatureZhao ATNEI NIH HHSNational Eye InstituteResearch to Prevent BlindnessNational Institutes of Health61-66https://www.ebi.ac.uk/biostudies/studies/S-EPMC11735302biostudies-literatureUnknown270<h4>Purpose</h4>To determine the association between dry eye disease (DED) and mental health conditions in a sociodemographically diverse nationwide population of Americans.<h4>Design</h4>Cross-sectional study.<h4>Methods</h4>We used the National Institute of Health's All of Us Research Program database to identify 18257 participants with DED who were propensity score matched in a 1:3 ratio to participants without DED. Univariate and multivariable logistic regression models were used to assess associations between DED and mental health conditions (i.e., depressive disorders, anxiety, bipolar disorder, and schizophrenic spectrum disorder).<h4>Results</h4>Participants with DED had a significantly higher prevalence of depressive disorders (31.6% vs. 10.7%; P < .001), anxiety disorders (34.8% American journal of ophthalmologyAssociations Between Dry Eye Disease and Mental Health Conditions in the All of Us Research Program.PMC11735302P30 EY001583Zhao ATHe JLei YYing GSChen YfalseAssociations Between Dry Eye Disease and Mental Health Conditions in the All of Us Research Program.<h4>Purpose</h4>To determine the association between dry eye disease (DED) and mental health conditions in a sociodemographically diverse nationwide population of Americans.<h4>Design</h4>Cross-sectional study.<h4>Methods</h4>We used the National Institute of Health's All of Us Research Program database to identify 18257 participants with DED who were propensity score matched in a 1:3 ratio to participants without DED. Univariate and multivariable logistic regression models were used to assess associations between DED and mental health conditions (i.e., depressive disorders, anxiety, bipolar disorder, and schizophrenic spectrum disorder).<h4>Results</h4>Participants with DED had a significantly higher prevalence of depressive disorders (31.6% vs. 10.7%; P < .001), anxiety disorders (34.8% 2025-01-01T00:00:00Z2025 Feb2026-06-16T07:27:36.467Z2026-06-16T03:10:00.993ZS-EPMC117353023942402410.1016/j.ajo.2024.10.009