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Participants with eHHV-6B had higher risks of SLE and PAP; the former was validated in All of Us. eHHV-6B-positivity and high SLE disease "],"journal":["Nature genetics"],"pagination":["65-79"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11735405"],"repository":["biostudies-literature"],"pubmed_title":["Blood DNA virome associates with autoimmune diseases and COVID-19."],"pmcid":["PMC11735405"],"pubmed_authors":["Saito R","Momose M","Osawa T","Saito Y","Miyazaki Y","Nakagawa I","Tanino Y","Ihara S","Sonehara K","Takaki M","Matsuda F","Watanabe C","Hosoda C","Mashimo S","Nakagawa A","Ohshima S","Ogata T","Takayanagi N","Watanabe H","Imafuku S","Isogai S","Watanabe M","Watanabe K","Uchida T","Tsuburai T","Watanabe R","Fukuyama S","Uchida S","Higasa K","Kita T","Kashiwada T","Ishitsuka Y","Yatomi M","Kuse N","Kanda H","Kagyo J","Nishitsuji M","Morisaki H","Furuta J","Japan COVID-19 Task Force","Saito F","Uchida A","Saito H","Hanada S","Kan-O K","Kishi H","Makino 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We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus. Participants with eHHV-6B had higher risks of SLE and PAP; the former was validated in All of Us. eHHV-6B-positivity and high SLE disease ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-02T19:06:25.158Z","creation":"2025-04-05T09:30:41.85Z"},"accession":"S-EPMC11735405","cross_references":{"pubmed":["39753770"],"doi":["10.1038/s41588-024-02022-z"]}}