biostudies-literatureWong RJNCATS NIH HHSNIDDK NIH HHSNIA NIH HHS464-471https://www.ebi.ac.uk/biostudies/studies/S-EPMC11735693biostudies-literatureUnknown59(5)<h4>Goals and background</h4>Patients with cirrhosis undergoing liver transplant evaluation have high rates of pain and mental health comorbidities; both may significantly impair health-related quality of life (HRQL). We investigated the association between pain, anxiety/depression, and HRQL in this population.<h4>Study</h4>In 62 patients with cirrhosis undergoing liver transplant evaluation, we performed 4 validated assessments to characterize: pain (Brief Pain Inventory-Short Form, BPI-SF), anxiety (Generalized Anxiety Disorder-7), depression (Patient Health Questionnaire-8), and liver-specific HRQL (Chronic Liver Disease Questionnaire). The presence of pain was determined using the BPI-SF screening question. Linear regression was used to identify demographic or clinical factors predictiJournal of clinical gastroenterologyThe Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation.PMC11735693P30 DK026743KL2 TR001870R01 AG059183K24 AG080021K23 DK135901Stark Kent DWong RJSharma ALai JCSeal KHSeetharaman SLoeb RRubin JBBarry FfalseThe Complex Relationship Between Pain, Mental Health, and Quality-of-Life in Patients With Cirrhosis Undergoing Liver Transplant Evaluation.<h4>Goals and background</h4>Patients with cirrhosis undergoing liver transplant evaluation have high rates of pain and mental health comorbidities; both may significantly impair health-related quality of life (HRQL). We investigated the association between pain, anxiety/depression, and HRQL in this population.<h4>Study</h4>In 62 patients with cirrhosis undergoing liver transplant evaluation, we performed 4 validated assessments to characterize: pain (Brief Pain Inventory-Short Form, BPI-SF), anxiety (Generalized Anxiety Disorder-7), depression (Patient Health Questionnaire-8), and liver-specific HRQL (Chronic Liver Disease Questionnaire). The presence of pain was determined using the BPI-SF screening question. Linear regression was used to identify demographic or clinical factors predicti2025-01-01T00:00:00Z2025 May-Jun 012026-06-06T08:25:50.051Z2026-05-27T03:12:10.449ZS-EPMC117356933900861410.1097/mcg.000000000000202810.1097/MCG.0000000000002028