{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ramanujam H"],"funding":["US National Institutes of Health","Foreign, Commonwealth and Development Office of the United Kingdom","NIAID NIH HHS","Indian Council of Medical Research","Pennsylvania Agricultural Experiment Station","Huck Institutes of the Life Sciences","Bill and Melinda Gates Foundation"],"pagination":["ofae733"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11736417"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<h4>Background</h4>India has the highest global burden of human tuberculosis (TB) and the largest cattle herd with endemic bovine TB (bTB). However, the extent of cross-species transmission and the zoonotic spillover risk, including drug-resistant <i>Mycobacterium tuberculosis</i> complex (MTBC) strains circulating in cattle, remain uncharacterized.<h4>Methods</h4>To address this major knowledge gap, we investigated tissue samples from 500 apparently healthy cattle at a slaughterhouse in Chennai, India. Whole genome sequencing was performed to characterize the isolates.<h4>Results</h4>Sixteen animals (32 per 1000 [95% confidence interval, 16-47]) were MTBC-positive, a rate that is nearly an order of magnitude greater than the reported human TB incidence in the region. Thirteen isolates wer"],"journal":["Open forum infectious diseases"],"pubmed_title":["Recovery of &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; Complex Isolates Including Pre-Extensively Drug-Resistant Strains From Cattle at a Slaughterhouse in Chennai, India."],"pmcid":["PMC11736417"],"funding_grant_id":["R01 AI170753","ZON/41/2019/ECD-II","INV-055079","1R01A1170753-01A1"],"pubmed_authors":["Palanisamy M","Shanmugavel A","Kandasamy D","Radhakrishnan A","Ravi N","Refaya AK","Radhika G","Shanmugam S","Stuber TP","Ravi R","Thiruvengadam K","Ramanujam H","Kapur V","Palaniyandi K","Pazhanivel N"],"additional_accession":[]},"is_claimable":false,"name":"Recovery of &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; Complex Isolates Including Pre-Extensively Drug-Resistant Strains From Cattle at a Slaughterhouse in Chennai, India.","description":"<h4>Background</h4>India has the highest global burden of human tuberculosis (TB) and the largest cattle herd with endemic bovine TB (bTB). However, the extent of cross-species transmission and the zoonotic spillover risk, including drug-resistant <i>Mycobacterium tuberculosis</i> complex (MTBC) strains circulating in cattle, remain uncharacterized.<h4>Methods</h4>To address this major knowledge gap, we investigated tissue samples from 500 apparently healthy cattle at a slaughterhouse in Chennai, India. Whole genome sequencing was performed to characterize the isolates.<h4>Results</h4>Sixteen animals (32 per 1000 [95% confidence interval, 16-47]) were MTBC-positive, a rate that is nearly an order of magnitude greater than the reported human TB incidence in the region. Thirteen isolates wer","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-25T18:54:25.222Z","creation":"2025-04-06T07:45:26.735Z"},"accession":"S-EPMC11736417","cross_references":{"pubmed":["39822270"],"doi":["10.1093/ofid/ofae733"]}}