{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schramm S"],"funding":["Deutsche Gesetzliche Unfallversicherung"],"pagination":["e70061"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11736620"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Introduction</h4>The aim of the study was to estimate the population-based dementia incidence in Germany over a period of two decades.<h4>Methods</h4>We analyzed data from 4814 participants of the population-based Heinz Nixdorf Recall study (49.8% men, 45-75 years at baseline period 2000-2003), who have been monitored for the occurrence of cognitive decline and dementia. We calculated the cumulative incidence of dementia and its major subtypes and the incidence rate per 1000 person-years over two decades.<h4>Results</h4>During a median follow-up of 18.2 (Q1-Q3: 11.3-20.6) years, a total of 298 participants (6.2%) developed dementia (22.1% Alzheimer´s disease, 23.5% vascular dementia, 15.1% mixed dementia, 9.1% other dementia, 30.2% unspecified). The overall incidence rate was 3.9 per 1000 person-years.<h4>Discussion</h4>Our study is the only current population-based study in Germany that estimates the incidence of dementia. In order to reduce the high proportion of unspecific dementia diagnoses, diagnostics urgently need to be improved.<h4>Highlights</h4>New data on the incidence of dementia in Germany in participants ≥45 years of age.Participants have been monitored for dementia incidence over two decades.The overall incidence in our cohort was 3.9 per 1000 person-years.Many patients had unspecific dementia diagnoses in their medical records.Further diagnostic evaluation should be available for all dementia patients."],"journal":["Alzheimer's & dementia (Amsterdam, Netherlands)"],"pubmed_title":["Incidence of dementia in the German Heinz Nixdorf Recall study over 20 years."],"pmcid":["PMC11736620"],"funding_grant_id":["FF‐FP295"],"pubmed_authors":["Gronewold J","Jockel KH","Schramm S","Schmidt B","Jokisch M","Rinck C","Hermann D","Husing A","Stang A","Krizanovic N"],"additional_accession":[]},"is_claimable":false,"name":"Incidence of dementia in the German Heinz Nixdorf Recall study over 20 years.","description":"<h4>Introduction</h4>The aim of the study was to estimate the population-based dementia incidence in Germany over a period of two decades.<h4>Methods</h4>We analyzed data from 4814 participants of the population-based Heinz Nixdorf Recall study (49.8% men, 45-75 years at baseline period 2000-2003), who have been monitored for the occurrence of cognitive decline and dementia. We calculated the cumulative incidence of dementia and its major subtypes and the incidence rate per 1000 person-years over two decades.<h4>Results</h4>During a median follow-up of 18.2 (Q1-Q3: 11.3-20.6) years, a total of 298 participants (6.2%) developed dementia (22.1% Alzheimer´s disease, 23.5% vascular dementia, 15.1% mixed dementia, 9.1% other dementia, 30.2% unspecified). The overall incidence rate was 3.9 per 1000 person-years.<h4>Discussion</h4>Our study is the only current population-based study in Germany that estimates the incidence of dementia. In order to reduce the high proportion of unspecific dementia diagnoses, diagnostics urgently need to be improved.<h4>Highlights</h4>New data on the incidence of dementia in Germany in participants ≥45 years of age.Participants have been monitored for dementia incidence over two decades.The overall incidence in our cohort was 3.9 per 1000 person-years.Many patients had unspecific dementia diagnoses in their medical records.Further diagnostic evaluation should be available for all dementia patients.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan-Mar","modification":"2026-06-02T19:07:31.148Z","creation":"2025-04-06T01:55:30.866Z"},"accession":"S-EPMC11736620","cross_references":{"pubmed":["39822293"],"doi":["10.1002/dad2.70061"]}}