{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Possa-Paranhos IC"],"funding":["Eunice Kennedy Shriver National Institute of Child Health and Human Development","HHS","NICHD NIH HHS","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","Hamilton Health Sciences","Foundation for Prader-Willi Research","Brain and Behavior Research Foundation","National Institutes of Health","NIH"],"pagination":["379-410"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11737543"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["603(2)"],"pubmed_abstract":["Although mammals resist both acute weight loss and weight gain, the neural circuitry mediating bi-directional defense against weight change is incompletely understood. Global constitutive deletion of the melanocortin-3-receptor (MC3R) impairs the behavioural response to both anorexic and orexigenic stimuli, with MC3R knockout mice demonstrating increased weight gain following anabolic challenges and increased weight loss following anorexic challenges (i.e. impaired energy rheostasis). However, the brain regions mediating this phenotype are not well understood. Here, we utilized MC3R floxed mice and viral injections of Cre-recombinase to selectively delete MC3R from the medial hypothalamus (MH) in adult mice. Behavioural assays were performed on these animals to test the role of MC3R in MH "],"journal":["The Journal of physiology"],"pubmed_title":["Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice."],"pmcid":["PMC11737543"],"funding_grant_id":["R01 HD113522","R00DK127065","R01HD113522","100000874","R00 DK127065"],"pubmed_authors":["Congdon S","Butts J","Possa-Paranhos IC","Nelson C","Sweeney P","Pyszka E","Cho D"],"additional_accession":[]},"is_claimable":false,"name":"Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice.","description":"Although mammals resist both acute weight loss and weight gain, the neural circuitry mediating bi-directional defense against weight change is incompletely understood. Global constitutive deletion of the melanocortin-3-receptor (MC3R) impairs the behavioural response to both anorexic and orexigenic stimuli, with MC3R knockout mice demonstrating increased weight gain following anabolic challenges and increased weight loss following anorexic challenges (i.e. impaired energy rheostasis). However, the brain regions mediating this phenotype are not well understood. Here, we utilized MC3R floxed mice and viral injections of Cre-recombinase to selectively delete MC3R from the medial hypothalamus (MH) in adult mice. Behavioural assays were performed on these animals to test the role of MC3R in MH ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-06T07:39:10.339Z","creation":"2026-05-27T03:11:47.255Z"},"accession":"S-EPMC11737543","cross_references":{"pubmed":["39718394"],"doi":["10.1113/JP286699"]}}