{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim S"],"funding":["Korea Health Industry Development Institute","National Research Foundation of Korea"],"pagination":["387-393"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11740091"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(3)"],"pubmed_abstract":["Antibody-recruiting molecules (ARMs) have emerged as a promising strategy for enhancing immune responses against pathogens and cancer cells. In this study, we developed a novel class of antibacterial ARMs utilizing siderophores, small iron-chelating compounds, as targeting motifs. Siderophores naturally exhibit high specificity for bacterial pathogens due to their role in iron acquisition, making them ideal candidates for selective targeting. We identified a potent ARM, GNP3, comprising MECAM, a siderophore mimetic, and 2,4-dinitrophenyl (DNP), a motif recognized by endogenous antibodies, connected <i>via</i> a flexible linker. GNP3 binds simultaneously to both anti-DNP antibody and the siderophore receptor, FepA, facilitating the targeted deposition of antibodies on the surface of FepA-ex"],"journal":["RSC chemical biology"],"pubmed_title":["Siderophore-based targeted antibody recruitment for promoting immune responses towards Gram-negative pathogens."],"pmcid":["PMC11740091"],"funding_grant_id":["HR22C1734","NRF-2021R1A2C1094331","RS-2023-00259824"],"pubmed_authors":["Kim S","Kim DH","Park HS","Kim DY","Choi CH","Oh J","Kim HJ","Kang MJ","Joh H"],"additional_accession":[]},"is_claimable":false,"name":"Siderophore-based targeted antibody recruitment for promoting immune responses towards Gram-negative pathogens.","description":"Antibody-recruiting molecules (ARMs) have emerged as a promising strategy for enhancing immune responses against pathogens and cancer cells. In this study, we developed a novel class of antibacterial ARMs utilizing siderophores, small iron-chelating compounds, as targeting motifs. Siderophores naturally exhibit high specificity for bacterial pathogens due to their role in iron acquisition, making them ideal candidates for selective targeting. We identified a potent ARM, GNP3, comprising MECAM, a siderophore mimetic, and 2,4-dinitrophenyl (DNP), a motif recognized by endogenous antibodies, connected <i>via</i> a flexible linker. GNP3 binds simultaneously to both anti-DNP antibody and the siderophore receptor, FepA, facilitating the targeted deposition of antibodies on the surface of FepA-ex","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T13:46:52.854Z","creation":"2025-04-04T13:46:52.854Z"},"accession":"S-EPMC11740091","cross_references":{"pubmed":["39830684"],"doi":["10.1039/d4cb00293h"]}}