{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jamil MU"],"funding":["NEI NIH HHS"],"pagination":["16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11741063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Purpose
To evaluate visibility of a sub-band posterior to the external limiting membrane (ELM) and assess its age-associated variation.Methods
In a retrospective cross-sectional study, normal eyes were imaged using a high-resolution spectral-domain optical coherence tomography (SD-OCT) prototype (2.7-µm axial resolution). Volume fusion of six sequential scans (each 500 × 500 A-scans over 6 mm × 6 mm) was performed in the motion correction and volume reconstruction in OCT (MoReOCT) framework to enhance feature visibility in OCT. The subjects were divided into three groups: young (21-40 years old), middle (41-60 years old), and older (>60 years old). Three expert graders assessed the visibility of the sub-band on B-scans, and its A-scan intensity relative to ELM intensity (pe"],"journal":["Translational vision science & technology"],"pubmed_title":["High-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane."],"pmcid":["PMC11741063"],"funding_grant_id":["R01 EY011289","R01 EY034080"],"pubmed_authors":["Duker JS","Jamil MU","Fujimoto JG","Kaiser S","Waheed NK","Ploner SB","Desai S","Abu-Qamar O","Witkin AJ","Yaghy A","Won J","Takahashi H","Maier A","Marmalidou A","Hwang Y","Zhao PY"],"additional_accession":[]},"is_claimable":false,"name":"High-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane.","description":"Purpose
To evaluate visibility of a sub-band posterior to the external limiting membrane (ELM) and assess its age-associated variation.Methods
In a retrospective cross-sectional study, normal eyes were imaged using a high-resolution spectral-domain optical coherence tomography (SD-OCT) prototype (2.7-µm axial resolution). Volume fusion of six sequential scans (each 500 × 500 A-scans over 6 mm × 6 mm) was performed in the motion correction and volume reconstruction in OCT (MoReOCT) framework to enhance feature visibility in OCT. The subjects were divided into three groups: young (21-40 years old), middle (41-60 years old), and older (>60 years old). Three expert graders assessed the visibility of the sub-band on B-scans, and its A-scan intensity relative to ELM intensity (pe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-18T16:48:35.75Z","creation":"2025-04-07T04:15:49.926Z"},"accession":"S-EPMC11741063","cross_references":{"pubmed":["39813051"],"doi":["10.1167/tvst.14.1.16"]}}