biostudies-literatureJamil MUNEI NIH HHS16https://www.ebi.ac.uk/biostudies/studies/S-EPMC11741063biostudies-literatureUnknown14(1)<h4>Purpose</h4>To evaluate visibility of a sub-band posterior to the external limiting membrane (ELM) and assess its age-associated variation.<h4>Methods</h4>In a retrospective cross-sectional study, normal eyes were imaged using a high-resolution spectral-domain optical coherence tomography (SD-OCT) prototype (2.7-µm axial resolution). Volume fusion of six sequential scans (each 500 × 500 A-scans over 6 mm × 6 mm) was performed in the motion correction and volume reconstruction in OCT (MoReOCT) framework to enhance feature visibility in OCT. The subjects were divided into three groups: young (21-40 years old), middle (41-60 years old), and older (>60 years old). Three expert graders assessed the visibility of the sub-band on B-scans, and its A-scan intensity relative to ELM intensity (peTranslational vision science & technologyHigh-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane.PMC11741063R01 EY011289R01 EY034080Duker JSJamil MUFujimoto JGKaiser SWaheed NKPloner SBDesai SAbu-Qamar OWitkin AJYaghy AWon JTakahashi HMaier AMarmalidou AHwang YZhao PYfalseHigh-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane.<h4>Purpose</h4>To evaluate visibility of a sub-band posterior to the external limiting membrane (ELM) and assess its age-associated variation.<h4>Methods</h4>In a retrospective cross-sectional study, normal eyes were imaged using a high-resolution spectral-domain optical coherence tomography (SD-OCT) prototype (2.7-µm axial resolution). Volume fusion of six sequential scans (each 500 × 500 A-scans over 6 mm × 6 mm) was performed in the motion correction and volume reconstruction in OCT (MoReOCT) framework to enhance feature visibility in OCT. The subjects were divided into three groups: young (21-40 years old), middle (41-60 years old), and older (>60 years old). Three expert graders assessed the visibility of the sub-band on B-scans, and its A-scan intensity relative to ELM intensity (pe2025-01-01T00:00:00Z2025 Jan2025-04-18T16:48:35.75Z2025-04-07T04:15:49.926ZS-EPMC117410633981305110.1167/tvst.14.1.16