{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Osei EK"],"funding":["NIGMS NIH HHS"],"pubmed_abstract":["Bacteriophage research has experienced a renaissance in recent years, owing to their therapeutic potential and versatility in biotechnology, particularly in combating antibiotic resistant-bacteria along the farm-to-fork continuum. However, certain pathogens remain underexplored as targets for phage therapy, including the zoonotic pathogen <i>Streptococcus suis</i> which causes infections in pigs and humans. Despite global efforts, the genome of only one infective <i>S. suis</i> phage has been described. Here, we report the isolation of two phages that infect <i>S. suis</i>: Bonnie and Clyde. The phages infect 58% of 100 <i>S. suis</i> strains tested, including representatives of seven different serotypes and thirteen known sequence types from diverse geographical origins. Clyde suppressed "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.01.07.631744"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11741397"],"repository":["biostudies-literature"],"pubmed_title":["Isolation of phages infecting the zoonotic pathogen &lt;i&gt;Streptococcus suis&lt;/i&gt; reveals novel structural and genomic characteristics."],"pmcid":["PMC11741397"],"funding_grant_id":["R01 GM129325"],"pubmed_authors":["O'Hea R","Franz CMAP","O'Doherty A","Athalye A","Wilson M","Mahony J","Weinert LA","Cambillau C","Kenny JG","Osei EK","Hille F","Manzanilla EG","Murray GGR"],"additional_accession":[]},"is_claimable":false,"name":"Isolation of phages infecting the zoonotic pathogen &lt;i&gt;Streptococcus suis&lt;/i&gt; reveals novel structural and genomic characteristics.","description":"Bacteriophage research has experienced a renaissance in recent years, owing to their therapeutic potential and versatility in biotechnology, particularly in combating antibiotic resistant-bacteria along the farm-to-fork continuum. However, certain pathogens remain underexplored as targets for phage therapy, including the zoonotic pathogen <i>Streptococcus suis</i> which causes infections in pigs and humans. Despite global efforts, the genome of only one infective <i>S. suis</i> phage has been described. Here, we report the isolation of two phages that infect <i>S. suis</i>: Bonnie and Clyde. The phages infect 58% of 100 <i>S. suis</i> strains tested, including representatives of seven different serotypes and thirteen known sequence types from diverse geographical origins. Clyde suppressed ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-04-07T21:22:55.121Z","creation":"2025-04-05T21:20:35.264Z"},"accession":"S-EPMC11741397","cross_references":{"pubmed":["39829746"],"doi":["10.1101/2025.01.07.631744"]}}