biostudies-literatureUnknown67(1)Sabik JFMedtronic<h4>Objectives</h4>Safety, efficacy and durability are important considerations when selecting a bioprosthesis for aortic valve replacement (AVR). This study assessed 7-year clinical outcomes and haemodynamic performance of the Avalus bioprosthesis.<h4>Methods</h4>Patients indicated for surgical AVR were enrolled in this prospective, nonrandomized trial, conducted across 39 sites globally. The primary end-point of this analysis was freedom from surgical explant or percutaneous valve-in-valve reintervention due to structural valve deterioration (SVD) at 7 years of follow-up, determined using Kaplan-Meier (KM) analysis. We also evaluated a composite end-point of SVD and/or severe haemodynamic dysfunction requiring reintervention. Survival, valve-related safety events and haemodynamic performEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgeryezae414https://www.ebi.ac.uk/biostudies/studies/S-EPMC11742136biostudies-literatureSeven-year outcomes after surgical aortic valve replacement with a stented bovine pericardial bioprosthesis in over 1100 patients: a prospective multicentre analysis.PMC11742136Baig KGammie Jvan Leeuwen WJKress DRao VBaker COuda AIto SKaufeld TDuff SReardon MJFischbein MKlautz RJMLange RDawood MWu TBrown WMKshettry VRibakove GBapat VShrestha MCannon MKuhn ESchonhoff FBensari NFalk VLabrousse LKiefer PMoritz APatel HJSabik JFBorger MTahirkheli NOh JKFukuhara SPERIGON InvestigatorsPettersson GWalther TWahlers TKerendi FAldea GRaikar GGunzinger RAdams DHChu MCartier RKoprivanac MDagenais FKappetein APHagberg RBeaver TWeber AFullerton DCarrel TAlfieri OSvensson LMisfeld MRamlawi BSundt TRuel MHolubec TTakeda KMoront MGSteffen RJfalseSeven-year outcomes after surgical aortic valve replacement with a stented bovine pericardial bioprosthesis in over 1100 patients: a prospective multicentre analysis.<h4>Objectives</h4>Safety, efficacy and durability are important considerations when selecting a bioprosthesis for aortic valve replacement (AVR). This study assessed 7-year clinical outcomes and haemodynamic performance of the Avalus bioprosthesis.<h4>Methods</h4>Patients indicated for surgical AVR were enrolled in this prospective, nonrandomized trial, conducted across 39 sites globally. The primary end-point of this analysis was freedom from surgical explant or percutaneous valve-in-valve reintervention due to structural valve deterioration (SVD) at 7 years of follow-up, determined using Kaplan-Meier (KM) analysis. We also evaluated a composite end-point of SVD and/or severe haemodynamic dysfunction requiring reintervention. Survival, valve-related safety events and haemodynamic perform2024-01-01T00:00:00Z2024 Dec2026-06-01T20:05:50.247Z2026-05-20T03:08:30.158ZS-EPMC117421363956590510.1093/ejcts/ezae414