{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rodriguez-Marino N"],"funding":["NCATS NIH HHS","EMORY UNIVERSITY","NIDDK NIH HHS","NIAID NIH HHS","NIH","NIDDK","NIGMS NIH HHS"],"pagination":["1301-1313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11742265"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(6)"],"pubmed_abstract":["The impact of dietary fiber on intestinal T cell development is poorly understood. Here we show that a low fiber diet reduces MHC-II antigen presentation by small intestinal epithelial cells (IECs) and consequently impairs development of CD4<sup>+</sup>CD8αα<sup>+</sup> intraepithelial lymphocytes (DP IELs) through changes to the microbiota. Dietary fiber supports colonization by Segmented Filamentous Bacteria (SFB), which induces the secretion of IFNγ by type 1 innate lymphoid cells (ILC1s) that lead to MHC-II upregulation on IECs. IEC MHC-II expression caused either by SFB colonization or exogenous IFNγ administration induced differentiation of DP IELs. Finally, we show that a low fiber diet promotes overgrowth of Bifidobacterium pseudolongum, and that oral administration of B. pseudolon"],"journal":["Mucosal immunology"],"pubmed_title":["Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4<sup>+</sup>CD8αα<sup>+</sup> intraepithelial T cells."],"pmcid":["PMC11742265"],"funding_grant_id":["R01 DK129950","UL1 TR002378","R35 GM142503","T32 AI106699"],"pubmed_authors":["Cervantes-Barragan L","Scharer CD","Seto E","Rivera-Rodriguez DE","Jones RM","Rodriguez-Marino N","Gracien I","Royer CJ","Gracz AD"],"additional_accession":[]},"is_claimable":false,"name":"Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4<sup>+</sup>CD8αα<sup>+</sup> intraepithelial T cells.","description":"The impact of dietary fiber on intestinal T cell development is poorly understood. Here we show that a low fiber diet reduces MHC-II antigen presentation by small intestinal epithelial cells (IECs) and consequently impairs development of CD4<sup>+</sup>CD8αα<sup>+</sup> intraepithelial lymphocytes (DP IELs) through changes to the microbiota. Dietary fiber supports colonization by Segmented Filamentous Bacteria (SFB), which induces the secretion of IFNγ by type 1 innate lymphoid cells (ILC1s) that lead to MHC-II upregulation on IECs. IEC MHC-II expression caused either by SFB colonization or exogenous IFNγ administration induced differentiation of DP IELs. Finally, we show that a low fiber diet promotes overgrowth of Bifidobacterium pseudolongum, and that oral administration of B. pseudolon","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-02T20:12:15.434Z","creation":"2025-04-05T21:19:26.055Z"},"accession":"S-EPMC11742265","cross_references":{"pubmed":["39244090"],"doi":["10.1016/j.mucimm.2024.08.010"]}}