biostudies-literatureUnknown15Wu B<h4>Background</h4>The body of research on tumor-infiltrating lymphocytes (TILs) is expanding rapidly; yet, a comprehensive analysis of related publications has been notably absent.<h4>Objective</h4>This study utilizes bibliometric methodologies to identify emerging research hotspots and to map the distribution of tumor-infiltrating lymphocyte research.<h4>Methods</h4>Literature from the Web of Science database was analyzed and visualized using VOSviewer, CiteSpace, Scimago Graphica, R-bibliometrix, and R packages.<h4>Results</h4>Research on tumor-infiltrating lymphocytes began in 1975 and has experienced significant growth, particularly after 2015. Leading contributors include the United States, the National Cancer Institute, the journal Cancer Immunology Immunotherapy, and researcher SteFrontiers in immunology1511866https://www.ebi.ac.uk/biostudies/studies/S-EPMC11743541biostudies-literatureThe global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis.PMC11743541Liu JQiao CWu BWang XLi RLuo DfalseThe global trends and distribution in tumor-infiltrating lymphocytes over the past 49 years: bibliometric and visualized analysis.<h4>Background</h4>The body of research on tumor-infiltrating lymphocytes (TILs) is expanding rapidly; yet, a comprehensive analysis of related publications has been notably absent.<h4>Objective</h4>This study utilizes bibliometric methodologies to identify emerging research hotspots and to map the distribution of tumor-infiltrating lymphocyte research.<h4>Methods</h4>Literature from the Web of Science database was analyzed and visualized using VOSviewer, CiteSpace, Scimago Graphica, R-bibliometrix, and R packages.<h4>Results</h4>Research on tumor-infiltrating lymphocytes began in 1975 and has experienced significant growth, particularly after 2015. Leading contributors include the United States, the National Cancer Institute, the journal Cancer Immunology Immunotherapy, and researcher Ste2024-01-01T00:00:00Z20242025-04-22T05:21:34.405Z2025-04-05T21:19:41.806ZS-EPMC117435413983513510.3389/fimmu.2024.1511866