{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Zhang X"],"pubmed_abstract":["<h4>Introduction</h4>Esophageal squamous cell carcinoma (ESCC) accounts for 80% of esophageal cancer (EC) worldwide. The molecular characteristics of locally advanced ESCC have been extensively studied.<h4>Methods</h4>In this study, we investigate the genomic and transcriptomic characteristics and try to provide the basic T-cell receptors (TCRs) dynamics and its genomic and transcriptome association during the radiochemotherapy of ESCC using multi-omics analysis.<h4>Results</h4>A total of 23 patients with pathologic diagnoses of locally advanced ESCC were enrolled. The median tumor mutational burden (TMB) of the 23 ESCC patients were 3.47 mutations/ Mb (mega-base). The TP53, RTK/RAS, and NOTCH pathways were concurrently prevalent in ESCC. Besides, some less prevalent pathways, including WN"],"journal":["Frontiers in oncology"],"pagination":["1495200"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11743576"],"repository":["biostudies-literature"],"pubmed_title":["Genomic, transcriptomic, and T cell receptor profiling in stratifying response to first-line chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma."],"pmcid":["PMC11743576"],"pubmed_authors":["Lian J","Li H","Li Z","Liang H","Jia S","Zhang X","Chen F","Wang W","Wang K","Xue H"],"additional_accession":[]},"is_claimable":false,"name":"Genomic, transcriptomic, and T cell receptor profiling in stratifying response to first-line chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma.","description":"<h4>Introduction</h4>Esophageal squamous cell carcinoma (ESCC) accounts for 80% of esophageal cancer (EC) worldwide. The molecular characteristics of locally advanced ESCC have been extensively studied.<h4>Methods</h4>In this study, we investigate the genomic and transcriptomic characteristics and try to provide the basic T-cell receptors (TCRs) dynamics and its genomic and transcriptome association during the radiochemotherapy of ESCC using multi-omics analysis.<h4>Results</h4>A total of 23 patients with pathologic diagnoses of locally advanced ESCC were enrolled. The median tumor mutational burden (TMB) of the 23 ESCC patients were 3.47 mutations/ Mb (mega-base). The TP53, RTK/RAS, and NOTCH pathways were concurrently prevalent in ESCC. Besides, some less prevalent pathways, including WN","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-22T05:15:40.143Z","creation":"2025-04-05T21:15:59.319Z"},"accession":"S-EPMC11743576","cross_references":{"pubmed":["39834937"],"doi":["10.3389/fonc.2024.1495200"]}}