biostudies-literatureRui MNatural Science Foundation for Young Scholars of Jiangsu ProvinceOrthopaedic Medical Innovation Center of JiangsuNational Key R&D Program of China, MOSTProgram of Wuxi Health CommissionWuxi Health and Family Planning Commission FoundationOutstanding Youth Project of Anhui University natural scienceKey Laboratory of Orthopaedics of SuzhouJiangyin Young and Middle-aged Excellent Medical Talents Training ProjectYouth Scientific Research Project of Jiangyin Health CommissionPriority Academic Program Development of Jiangsu Higher Education InstitutionsNational Natural Science Foundation of Chinae2409636https://www.ebi.ac.uk/biostudies/studies/S-EPMC11744641biostudies-literatureUnknown12(3)Hypoxia and reactive oxygen species (ROS) overaccumulation cause persistent oxidative stress and impair intrinsic regenerative potential upon tissue injury. For local tissue injury with hypoxia, such as bone fracture and defects, a localized-sufficient oxygen supply is highly desirable but remains challenging. Therefore, to explore a strategy and its intrinsic mechanism for supplying oxygen locally and remodeling the regenerative microenvironment, an innovative oxygenating hydrogel microsphere system with sustained oxygenation and antioxidant properties is introduced by loading CaO₂@SiO₂@PDA (CSP) nanoparticles. Specifically, the CSP nanoparticles exhibited broad-spectrum free radicals scavenging ability, along with prolonged controlled-release of oxygen once integratAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Implantable Multifunctional Micro-Oxygen Reservoir System for Promoting Vascular-Osteogenesis via Remodeling Regenerative Microenvironment.PMC11744641CXZX202209Z202008SZS2022017J201811BK20220314Q20230182030068Q202353JYOYT2023032023AH020050821724852023YFC2509900Yang HYang YRen KShi QHui YCui WRui MMa TShen HWang JMao JWu HfalseImplantable Multifunctional Micro-Oxygen Reservoir System for Promoting Vascular-Osteogenesis via Remodeling Regenerative Microenvironment.Hypoxia and reactive oxygen species (ROS) overaccumulation cause persistent oxidative stress and impair intrinsic regenerative potential upon tissue injury. For local tissue injury with hypoxia, such as bone fracture and defects, a localized-sufficient oxygen supply is highly desirable but remains challenging. Therefore, to explore a strategy and its intrinsic mechanism for supplying oxygen locally and remodeling the regenerative microenvironment, an innovative oxygenating hydrogel microsphere system with sustained oxygenation and antioxidant properties is introduced by loading CaO₂@SiO₂@PDA (CSP) nanoparticles. Specifically, the CSP nanoparticles exhibited broad-spectrum free radicals scavenging ability, along with prolonged controlled-release of oxygen once integrat2025-01-01T00:00:00Z2025 Jan2025-04-03T23:58:06.312Z2025-04-03T23:58:06.312ZS-EPMC117446413958855310.1002/advs.202409636