{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21"],"submitter":["Yu W"],"pubmed_abstract":["Orthogonal self-assembly represents a useful methodology to construct supramolecular polymers with AA- and AB-type monomers, as commonly used for covalently linked polymers. So far, the design of such monomers has relied heavily on three-dimensional macrocycles, and the use of two-dimensional shape-persistent macrocycles for this purpose remains rather rare. Here, we demonstrate a dimerization motif based on a hydrogen-bonded macrocycle that can be effectively applied to form orthogonal supramolecular polymers. The macrocycle-mediated connectivity was confirmed by single-crystal X-ray diffraction, which revealed a unique 2:2 binding motif between host and guest, bridged by two cationic pyridinium end groups through π-stacking interactions and other cooperative intermolecular forces. Zinc io"],"journal":["Beilstein journal of organic chemistry"],"pagination":["179-188"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11744735"],"repository":["biostudies-literature"],"pubmed_title":["Hydrogen-bonded macrocycle-mediated dimerization for orthogonal supramolecular polymerization."],"pmcid":["PMC11744735"],"pubmed_authors":["Li X","Yang Z","Yu C","Yuan L","Yu W"],"additional_accession":[]},"is_claimable":false,"name":"Hydrogen-bonded macrocycle-mediated dimerization for orthogonal supramolecular polymerization.","description":"Orthogonal self-assembly represents a useful methodology to construct supramolecular polymers with AA- and AB-type monomers, as commonly used for covalently linked polymers. So far, the design of such monomers has relied heavily on three-dimensional macrocycles, and the use of two-dimensional shape-persistent macrocycles for this purpose remains rather rare. Here, we demonstrate a dimerization motif based on a hydrogen-bonded macrocycle that can be effectively applied to form orthogonal supramolecular polymers. The macrocycle-mediated connectivity was confirmed by single-crystal X-ray diffraction, which revealed a unique 2:2 binding motif between host and guest, bridged by two cationic pyridinium end groups through π-stacking interactions and other cooperative intermolecular forces. Zinc io","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-05T09:32:50.18Z","creation":"2025-04-05T09:32:50.18Z"},"accession":"S-EPMC11744735","cross_references":{"pubmed":["39834893"],"doi":["10.3762/bjoc.21.10"]}}