{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang L"],"funding":["Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","CAMS Endowment Fund","Fundamental Research Funds for Central Universities","National Natural Science Foundation of China","Overseas Expertise Introduction Center for Discipline Innovation (\"111Center\")"],"pagination":["83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11744981"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["Influenza-related acute lung injury is a life-threatening condition primarily caused by uncontrolled replication of the influenza virus and intense proinflammatory responses. Cereblon (CRBN) is a protein known for its role in the ubiquitin-proteasome system and as a target of the drug thalidomide. However, the function of CRBN in influenza virus infection remains poorly understood. In this study, we investigated the impact of CRBN on A/Puerto Rico/8/34 (PR8) influenza virus-induced lung injury and its potential as a therapeutic target. Knocking down CRBN in vitro significantly reduces PR8-induced cell death. Using Sftpc-Cre; Crbn<sup>flox/flox</sup> lung-specific Crbn knockout mice, we demonstrated that Crbn deficiency significantly decreased mortality, weight loss, lung pathology, edema, "],"journal":["BMC infectious diseases"],"pubmed_title":["Lung-specific CRBN knockout attenuates influenza a virus-induced acute lung injury in mice: a potential therapeutic approach."],"pmcid":["PMC11744981"],"funding_grant_id":["2021-CAMS-JZ001","BP0820029","2021-I2M-1-022","2017PT31017","81788101","81570077"],"pubmed_authors":["Zhang Y","Wang W","Jiang C","Zhang L","Wang X","Chang J","Zhou Y","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"Lung-specific CRBN knockout attenuates influenza a virus-induced acute lung injury in mice: a potential therapeutic approach.","description":"Influenza-related acute lung injury is a life-threatening condition primarily caused by uncontrolled replication of the influenza virus and intense proinflammatory responses. Cereblon (CRBN) is a protein known for its role in the ubiquitin-proteasome system and as a target of the drug thalidomide. However, the function of CRBN in influenza virus infection remains poorly understood. In this study, we investigated the impact of CRBN on A/Puerto Rico/8/34 (PR8) influenza virus-induced lung injury and its potential as a therapeutic target. Knocking down CRBN in vitro significantly reduces PR8-induced cell death. Using Sftpc-Cre; Crbn<sup>flox/flox</sup> lung-specific Crbn knockout mice, we demonstrated that Crbn deficiency significantly decreased mortality, weight loss, lung pathology, edema, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-03T23:58:07.634Z","creation":"2025-04-03T23:58:07.634Z"},"accession":"S-EPMC11744981","cross_references":{"pubmed":["39833740"],"doi":["10.1186/s12879-025-10490-9"]}}