{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gong Z"],"funding":["Department of Education of Guangdong Province","National Natural Science Foundation of China"],"pagination":["29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11748312"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims to develop a novel composite material combining enzymatic nanoparticles and nerve growth factor (NGF) to modulate the immune microenvironment and enhance SCI repair.<h4>Methods</h4>CeMn nanoparticles (NP) and CeMn NP-polyethylene glycol (PEG) nanozymes were synthesized via sol-gel reaction and DSPE-mPEG modification. Transmission Electron Microscopy, Selected-Area Electron Diffraction, X-ray Diffraction and X-ray Photoelectron Spectroscopy confirmed their crystalline structure, mixed-valence states, and redox properties. Size uniformity, biocompatibility, and catalytic activity "],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration."],"pmcid":["PMC11748312"],"funding_grant_id":["32371438","2023ZDZX2012","82472498"],"pubmed_authors":["Wu J","Xia X","Jiang J","Li D","Lu X","Sun C","Ma X","Liu S","Lu F","Wang H","Gong Z","Chen Z","Wang X","Sun H","Zeng F"],"additional_accession":[]},"is_claimable":false,"name":"Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration.","description":"<h4>Background</h4>Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims to develop a novel composite material combining enzymatic nanoparticles and nerve growth factor (NGF) to modulate the immune microenvironment and enhance SCI repair.<h4>Methods</h4>CeMn nanoparticles (NP) and CeMn NP-polyethylene glycol (PEG) nanozymes were synthesized via sol-gel reaction and DSPE-mPEG modification. Transmission Electron Microscopy, Selected-Area Electron Diffraction, X-ray Diffraction and X-ray Photoelectron Spectroscopy confirmed their crystalline structure, mixed-valence states, and redox properties. Size uniformity, biocompatibility, and catalytic activity ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-04T14:05:35.572Z","creation":"2025-04-04T14:05:35.572Z"},"accession":"S-EPMC11748312","cross_references":{"pubmed":["39833803"],"doi":["10.1186/s12951-025-03098-3"]}}