biostudies-literatureUnknown23(1)Liu X<h4>Background</h4>Previous studies have suggested oxidative stress may play a key role in the pathogenesis of retinopathy, while evidence from observational studies directly linking oxidative biomarkers to clinically relevant outcomes has been limited. This study aims to investigate the association between oxidative balance score (OBS) and prevalence of retinopathy in a nationally representative sample of U.S. adults, including both those with and without diabetes.<h4>Methods</h4>Data were obtained from the NHANES 2005-2008, including 3,287 participants. OBS was calculated from 16 dietary and 4 lifestyle components and categorized into tertiles. Weighted logistic regression was used to assess the association between OBS and retinopathy in the overall, diabetic, and non-diabetic populationJournal of translational medicine94https://www.ebi.ac.uk/biostudies/studies/S-EPMC11748554biostudies-literatureOxidative stress and retinopathy: evidence from epidemiological studies.PMC11748554Liu XLiu YChen NLi YLu JCui JChang YSong WfalseOxidative stress and retinopathy: evidence from epidemiological studies.<h4>Background</h4>Previous studies have suggested oxidative stress may play a key role in the pathogenesis of retinopathy, while evidence from observational studies directly linking oxidative biomarkers to clinically relevant outcomes has been limited. This study aims to investigate the association between oxidative balance score (OBS) and prevalence of retinopathy in a nationally representative sample of U.S. adults, including both those with and without diabetes.<h4>Methods</h4>Data were obtained from the NHANES 2005-2008, including 3,287 participants. OBS was calculated from 16 dietary and 4 lifestyle components and categorized into tertiles. Weighted logistic regression was used to assess the association between OBS and retinopathy in the overall, diabetic, and non-diabetic population2025-01-01T00:00:00Z2025 Jan2025-04-22T10:23:26.68Z2025-04-05T23:36:01.419ZS-EPMC117485543983837710.1186/s12967-025-06110-4