biostudies-literatureUnknown2(2)Ma TLipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons. Abnormal myelin sheath is associated with many neurological diseases. Meningioma-expressed antigen 6 (Mea6)/cutaneous T cell lymphoma-associated antigen 5C (cTAGE5C) plays an important role in vesicle trafficking from the endoplasmic reticulum (ER) to Golgi, and conditional knockout (cKO) of <i>Mea6</i> in the brain significantly affects neural development and brain function. However, whether the impaired brain function involves the development of oligodendrocytes and white matter beyond neurons remains unclear. In this study, by using different models of diffusion magnetic resonance imaging, we showed that cKO of <i>Mea6</i> in oligodendrocytes leads to significant impairment of the gross and micrLife metabolismload010https://www.ebi.ac.uk/biostudies/studies/S-EPMC11748983biostudies-literatureAblation of <i>Mea6/cTAGE5</i> in oligodendrocytes significantly impairs white matter structure and lipid content.PMC11748983Liu JShi LShui GXue RWang TMao WMa TZhang SWang YYu XXu ZfalseAblation of <i>Mea6/cTAGE5</i> in oligodendrocytes significantly impairs white matter structure and lipid content.Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons. Abnormal myelin sheath is associated with many neurological diseases. Meningioma-expressed antigen 6 (Mea6)/cutaneous T cell lymphoma-associated antigen 5C (cTAGE5C) plays an important role in vesicle trafficking from the endoplasmic reticulum (ER) to Golgi, and conditional knockout (cKO) of <i>Mea6</i> in the brain significantly affects neural development and brain function. However, whether the impaired brain function involves the development of oligodendrocytes and white matter beyond neurons remains unclear. In this study, by using different models of diffusion magnetic resonance imaging, we showed that cKO of <i>Mea6</i> in oligodendrocytes leads to significant impairment of the gross and micr2023-01-01T00:00:00Z2023 Apr2025-04-04T22:07:51.953Z2025-04-04T22:07:51.953ZS-EPMC117489833987273210.1093/lifemeta/load010