biostudies-literatureModha SMedical Research Councilveaf002https://www.ebi.ac.uk/biostudies/studies/S-EPMC11749082biostudies-literatureUnknown11(1)Anelloviruses are a group of small, circular, single-stranded DNA viruses that are found ubiquitously across mammalian hosts. Here, we explored a large number of publicly available human microbiome datasets and retrieved a total of 829 anellovirus genomes, substantially expanding the known diversity of these viruses. The majority of new genomes fall within the three major human anellovirus genera: Alphatorquevirus, Betatorquevirus, and Gammatorquevirus, while we also present new genomes of the under-sampled Hetorquevirus, Memtorquevirus, and Samektorquevirus genera. We performed recombination analysis and show evidence of extensive recombination across all human anelloviruses. Interestingly, more than 95% of the detected events are between members of the same geVirus evolutionExpanding the genomic diversity of human anelloviruses.PMC11749082MC_UU_1201412 MR/S502479/1Lytras SModha SHughes JOrton RJfalseExpanding the genomic diversity of human anelloviruses.Anelloviruses are a group of small, circular, single-stranded DNA viruses that are found ubiquitously across mammalian hosts. Here, we explored a large number of publicly available human microbiome datasets and retrieved a total of 829 anellovirus genomes, substantially expanding the known diversity of these viruses. The majority of new genomes fall within the three major human anellovirus genera: Alphatorquevirus, Betatorquevirus, and Gammatorquevirus, while we also present new genomes of the under-sampled Hetorquevirus, Memtorquevirus, and Samektorquevirus genera. We performed recombination analysis and show evidence of extensive recombination across all human anelloviruses. Interestingly, more than 95% of the detected events are between members of the same ge2025-01-01T00:00:00Z20252026-04-08T19:05:55.836Z2025-04-07T07:50:17.848ZS-EPMC117490823983967810.1093/ve/veaf002