{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(3)"],"submitter":["Li H"],"pubmed_abstract":["Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder threatening the eyesight. The pathogenic mechanisms and biomarkers reflecting disease severity and predicting treatment response require further exploration. Here, we performed a single-cell analysis of peripheral blood mononuclear cells (PBMC) obtained from eight patients with VKH disease and eight healthy controls to comprehensively delineate the changes in VKH disease. We showed a mixture of inflammation, effector, and exhausted states for PBMCs in VKH disease. Notably, our study implicated a newly identified B cell subset, natural killer-like B cells (K-BC) characterized by expressing CD19 and CD56, was correlated with VKH disease. K-BCs expanded in VKH disease, fell back after effective treatment, and promoted the di"],"journal":["Life medicine"],"pagination":["387-400"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11749541"],"repository":["biostudies-literature"],"pubmed_title":["Peripheral immune landscape and natural killer-like B cells in human Vogt-Koyanagi-Harada disease."],"pmcid":["PMC11749541"],"pubmed_authors":["Liu X","Li H","Zheng Y","Li Z","Wang R","Huang Z","Zhu L","Xie L","Yang S","Chen B","Su W","Ye J"],"additional_accession":[]},"is_claimable":false,"name":"Peripheral immune landscape and natural killer-like B cells in human Vogt-Koyanagi-Harada disease.","description":"Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder threatening the eyesight. The pathogenic mechanisms and biomarkers reflecting disease severity and predicting treatment response require further exploration. Here, we performed a single-cell analysis of peripheral blood mononuclear cells (PBMC) obtained from eight patients with VKH disease and eight healthy controls to comprehensively delineate the changes in VKH disease. We showed a mixture of inflammation, effector, and exhausted states for PBMCs in VKH disease. Notably, our study implicated a newly identified B cell subset, natural killer-like B cells (K-BC) characterized by expressing CD19 and CD56, was correlated with VKH disease. K-BCs expanded in VKH disease, fell back after effective treatment, and promoted the di","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T11:34:17.346Z","creation":"2025-04-05T11:34:17.346Z"},"accession":"S-EPMC11749541","cross_references":{"pubmed":["39872747"],"doi":["10.1093/lifemedi/lnac047"]}}