{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(6)"],"submitter":["Zhou D"],"pubmed_abstract":["The pathogenesis of several kidney diseases results in the eventual destruction of the renal tubular system, which can progress to end-stage renal disease. Previous studies have demonstrated the involvement of a population of SOX9-positive cells in kidney regeneration and repair process following kidney injury. However, the ability of these cells to autonomously generate kidney organoids has never been investigated. Here, we isolated SOX9<sup>+</sup> kidney progenitor cells (KPCs) from both mice and humans and tested their differentiation potential <i>in vitro</i>. The data showed that the human SOX9<sup>+</sup> KPC could self-assemble into organoids with kidney-like morphology. We also used single-cell RNA sequencing to characterize the organoid cell populations and identified four distin"],"journal":["Life medicine"],"pagination":["lnad047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11749593"],"repository":["biostudies-literature"],"pubmed_title":["Generation of renal tubular organoids from adult SOX9&lt;sup&gt;+&lt;/sup&gt; kidney progenitor cells."],"pmcid":["PMC11749593"],"pubmed_authors":["Duan J","Zuo W","Li D","Zhou D","Liu S","Wang Y","Nie H"],"additional_accession":[]},"is_claimable":false,"name":"Generation of renal tubular organoids from adult SOX9&lt;sup&gt;+&lt;/sup&gt; kidney progenitor cells.","description":"The pathogenesis of several kidney diseases results in the eventual destruction of the renal tubular system, which can progress to end-stage renal disease. Previous studies have demonstrated the involvement of a population of SOX9-positive cells in kidney regeneration and repair process following kidney injury. However, the ability of these cells to autonomously generate kidney organoids has never been investigated. Here, we isolated SOX9<sup>+</sup> kidney progenitor cells (KPCs) from both mice and humans and tested their differentiation potential <i>in vitro</i>. The data showed that the human SOX9<sup>+</sup> KPC could self-assemble into organoids with kidney-like morphology. We also used single-cell RNA sequencing to characterize the organoid cell populations and identified four distin","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-21T23:49:41.548Z","creation":"2025-04-05T19:21:41.834Z"},"accession":"S-EPMC11749593","cross_references":{"pubmed":["39872058"],"doi":["10.1093/lifemedi/lnad047"]}}