{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(2)"],"submitter":["Zhu J"],"pubmed_abstract":["Seipin plays a vital role in lipid droplet homeostasis, and its deficiency causes congenital generalized lipodystrophy type II in humans. It is not known whether the physiological defects are all caused by cellular lipid droplet defects. Loss-of-function mutation of <i>seip-1</i>, the <i>Caenorhabditis elegans</i> seipin ortholog, causes embryonic lethality and lipid droplet abnormality. We uncover <i>nhr-114</i> and <i>spin-4</i> as two suppressors of <i>seip-1</i> embryonic lethality. Mechanistically, <i>nhr-114</i> and <i>spin-4</i> act in the \"B12-one-carbon cycle-phosphatidylcholine (PC)\" axis, and reducing PC synthesis suppresses the embryonic lethality of <i>seip-1</i> mutants. Conversely, PC deficiency enhances the lipid droplet abnormality of <i>seip-1</i> mutants. The suppression"],"journal":["Life metabolism"],"pagination":["175-189"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11749705"],"repository":["biostudies-literature"],"pubmed_title":["Reduced phosphatidylcholine synthesis suppresses the embryonic lethality of seipin deficiency."],"pmcid":["PMC11749705"],"pubmed_authors":["Shui G","Zhu J","Yang L","Liang J","Huang X","Lam SM","Ding M"],"additional_accession":[]},"is_claimable":false,"name":"Reduced phosphatidylcholine synthesis suppresses the embryonic lethality of seipin deficiency.","description":"Seipin plays a vital role in lipid droplet homeostasis, and its deficiency causes congenital generalized lipodystrophy type II in humans. It is not known whether the physiological defects are all caused by cellular lipid droplet defects. Loss-of-function mutation of <i>seip-1</i>, the <i>Caenorhabditis elegans</i> seipin ortholog, causes embryonic lethality and lipid droplet abnormality. We uncover <i>nhr-114</i> and <i>spin-4</i> as two suppressors of <i>seip-1</i> embryonic lethality. Mechanistically, <i>nhr-114</i> and <i>spin-4</i> act in the \"B12-one-carbon cycle-phosphatidylcholine (PC)\" axis, and reducing PC synthesis suppresses the embryonic lethality of <i>seip-1</i> mutants. Conversely, PC deficiency enhances the lipid droplet abnormality of <i>seip-1</i> mutants. The suppression","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-21T23:53:28.478Z","creation":"2025-04-05T19:20:25.45Z"},"accession":"S-EPMC11749705","cross_references":{"pubmed":["39872351"],"doi":["10.1093/lifemeta/loac021"]}}