{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Bege M"],"funding":["University of Debrecen"],"pubmed_abstract":["Hydrogen sulfide (H<sub>2</sub>S) is an endogenous gasotransmitter with cardioprotective and antiviral effects. In this work, new cysteine-selective nucleoside-H<sub>2</sub>S-donor hybrid molecules were prepared by conjugating nucleoside biomolecules with a thiol-activatable dithioacetyl group. 5'-Dithioacetate derivatives were synthesized from the canonical nucleosides (uridine, adenosine, cytidine, guanosine and thymidine), and the putative 5'-thio metabolites were also produced from uridine and adenosine. According to our measurements made with an H<sub>2</sub>S-specific sensor, nucleoside dithioacetates are moderately fast H<sub>2</sub>S donors, the guanosine derivative showed the fastest kinetics and the adenosine derivative the slowest. The antioxidant activity of 5'-thionucleosides "],"journal":["Scientific reports"],"pagination":["2876"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11754443"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis, H&lt;sub&gt;2&lt;/sub&gt;S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5'-dithioacetates."],"pmcid":["PMC11754443"],"pubmed_authors":["Lovas M","Priksz D","Kajtar R","Weber J","Eskeif S","Borbas A","Herczegh P","Bege M","Lekli I","Bernat B","Hodek J","Bereczki I","Novak L","Kattoub RG"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, H&lt;sub&gt;2&lt;/sub&gt;S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5'-dithioacetates.","description":"Hydrogen sulfide (H<sub>2</sub>S) is an endogenous gasotransmitter with cardioprotective and antiviral effects. In this work, new cysteine-selective nucleoside-H<sub>2</sub>S-donor hybrid molecules were prepared by conjugating nucleoside biomolecules with a thiol-activatable dithioacetyl group. 5'-Dithioacetate derivatives were synthesized from the canonical nucleosides (uridine, adenosine, cytidine, guanosine and thymidine), and the putative 5'-thio metabolites were also produced from uridine and adenosine. According to our measurements made with an H<sub>2</sub>S-specific sensor, nucleoside dithioacetates are moderately fast H<sub>2</sub>S donors, the guanosine derivative showed the fastest kinetics and the adenosine derivative the slowest. The antioxidant activity of 5'-thionucleosides ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-19T18:22:52.985Z","creation":"2025-04-19T18:22:52.985Z"},"accession":"S-EPMC11754443","cross_references":{"pubmed":["39843902"],"doi":["10.1038/s41598-025-85351-1"]}}