biostudies-literatureThomas JLEfficacy and Mechanism Evaluation ProgrammeNational Institute for Health Research (NIHR)9https://www.ebi.ac.uk/biostudies/studies/S-EPMC11754546biostudies-literatureUnknown13(1)<h4>Purpose</h4>The landiolol and organ failure in patients with septic shock (STRESS-L study) included a pre-planned sub-study to assess the effect of landiolol treatment on inflammatory and metabolomic markers.<h4>Methods</h4>Samples collected from 91 patients randomised to STRESS-L were profiled for immune and metabolomic markers. A panel of pro- and anti-inflammatory cytokines were measured through commercially acquired multiplex Luminex assays and statistically analysed by individual and cluster-level analysis (patient). Metabolite fingerprinting was carried out by flow infusion electrospray ionisation high-resolution mass spectrometry and metabolomic data were analysed using the R-based platform MetaboAnalyst. The metabolites were identified using DIMEdb (dimedb.ibers.aber.ac.uk) froIntensive care medicine experimentalThe effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study.PMC1175454614/150/85Woods LFlanagan JWest JYoung DWane CRigden LBurgess RDhokia VGordon ACBanach DWaterman Ede Pinedo Artaraz ZFWalker JLittlewood KWalker RCockrell MGrainger LLanghon SLankester LDudgeon LWaddy SFinn SBrear TNeef MCalder VFletcher ATrumper EWaugh VSTRESS-L. collaboratorsHoward KAttwood BCurran LAnastasescu EWong CDepante MTWaite AChick KJHeyler SSankar VJenkins SCornell SClarey EWiseman STomkinson AWas BWhite BHindocha RLoko ZSBannon LTodd SWard SFTeixeira SPogson DWest RDooley NMcFarland DMurray VSnelson CPaul PMills CMcGee KCHormis AStones ECarter JAfzal ZBoyd OWells CStowe BHusain IWells BShortland MNoble HEllis KBoyle AGidda RHutchings MWillox FBall AChillingworth AHeddon SMcGhee CBetts RMcQueen SMills JMacColl HDunn LCampos SWynn ADrage SHarkett SSpencer KShanmugasundaram PO'Reilly KWoodford CCabreros LRowbotham ACrawley DMur LAJNotcheva GPhelps AJohnson RBabio-Galan MMurphy PMurphy NSmyth DPatrick-Heselton JJohnson ADukes SPhillips BPhillips CJohnson EPosnett CMacartney LBromilow JWhitehead LHinchley CKontogonis RIngham JBillyard TMcGurk FMacBrayne JLowthorpe VYoo JHowcroft CAnderson FWhiteley SPappa ECarrera RGordon JAppelboam RCharnock RCooper PJefferson PRowe JHillyer AStagg CDelgado CMcnamee JParis GDoble PJohnston AJohnston BWalters FNeal ASinger MPachoo KChambler DDaly ZDesai AChin YMShaw DThomas AButterworth-Cowin NTurton PScaife LShankar-Hari MCarle CCole LColleron RPope MOgg BMason TIlano DMason Sde Gordoa LOGettings SFinucane SChilvers RMitchell WColquhoun SCurtis KShafiq LMahroof RWarnes KCox GDavison JClarke CMitchell ASampson JRichmond KElcioglu ZPolgarova PBrett SClement ICampey LSweet KMcGinley LBociek AHossain ASingh MKotada MHaile SNandani AParekh DPope AGratrix AGrauNovellas NMariano VMcGregor EWebster DRichards CMcauley DCape AHarvey DO'Neill AGoulding MShrestha TReschreiter HEkbal NWard GKennedy-Kay SWard KHamilton DOMarron AStead SBrimfield LHarrison AMcKee RSalem KLyon ASpicer KSmith HYoungs NAli NSmith JEfford GWhitman ZChapman RScott ISTSmith RCoghlan PGordon EGordon AWestwood SCollier DWright KWilliams KStephenson JNdefo OGumbrill BLord JMParsons PTaylor AWright CPatel JHall KMartinez MLDickson SVarley JChristie MCrews MRojo RGibson CFilipe HMarner MWilliams PWilliams SWaterhouse CMccann JBewley JKelly SMew ICruz CMartinson VWlazly DTorlinski TKelly APatch SLeavy JMinnis CMcLeash KHall ADabbagh SMarchant GBreen AGoundry SPurnell RBean SLaybourne SWilmer LSpruce EKramaric TAnumakonda VReeves ERoy AWebb KCamilleri MWenstone RGray GTait MCottrell-Howe PPeters CCamporota LMcNeil MGill DVentura MPorter SGill MReay MRostron AEvans LHutter JSearles CLovegrove WMooradun MWilkinson JBergin CGrimmer LAbel LKeegan JJones JMaharajh ABercades GCahill HGuy ZPurcell IArias SSMacCallum NLim RRyan LCoey DManso KNutt CInglis SStanton LJackson DScott SMorris ACMorris LHolden JScott ZHolden SBrealey DHambrook GAntcliffe DAbrams JKimpton SYeung JMingo SDempsey FJackson RDespy LMoore VThomas JLCollins AAshcroft PReid KPorter JMoore LWilby EZwiggelaar KLatty LClark AMcaulay MShelton SChandler SBoulton ATalbot NHughes SArbane GShelley PMcAuley DKeenan SRoman JFRyu JGurung SOstermann MMcMillan HChu VWelters IKanu RBason NChan EJamadarkhana SKaye CInnes RJeffery LBriggs SDavies MGresty JHorton SDeol RPerkins GDSaluzzio RPOakley RHenderson SHass IOakley SDocking RConner LHopkins PShah NAKavanagh KNikitas NKirk JAndrews THosea JPrice GMelody TCorcoran KGupwell KDay ASquire RElkington TRogerson KMcNulty RHodgkinson SWoodward EBrady CLoew CVeenith TMeredith MStephens JRees JCronshaw HBarker GCamsooksai JFoster LPakou GBremmer PBurt KGraham CElHaddad AWade LBirkinshaw IShevlin CPawley CGarland ZGalvin HFilipowicz DPower SFrench RIsmail NLong KPower KFinney CHolder AHinds JLeaver STempleton MGrantham GClaridge HBamford AGohil SSpivey MRose SSim KRobinson LSim MMorgan CMalanjum LNandhabalan PJimenez DWhitehouse TBangash MPalmer NWiddop CWild LAllsop HCampbell BFellows ELall RAllsop LRobinson FfalseThe effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study.<h4>Purpose</h4>The landiolol and organ failure in patients with septic shock (STRESS-L study) included a pre-planned sub-study to assess the effect of landiolol treatment on inflammatory and metabolomic markers.<h4>Methods</h4>Samples collected from 91 patients randomised to STRESS-L were profiled for immune and metabolomic markers. A panel of pro- and anti-inflammatory cytokines were measured through commercially acquired multiplex Luminex assays and statistically analysed by individual and cluster-level analysis (patient). Metabolite fingerprinting was carried out by flow infusion electrospray ionisation high-resolution mass spectrometry and metabolomic data were analysed using the R-based platform MetaboAnalyst. The metabolites were identified using DIMEdb (dimedb.ibers.aber.ac.uk) fro2025-01-01T00:00:00Z2025 Jan2026-06-01T18:06:02.178Z2025-04-04T22:07:53.242ZS-EPMC117545463984138810.1186/s40635-024-00708-6