{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fu Z"],"funding":["NICHD NIH HHS","European Research Council","NIA NIH HHS","NIDA NIH HHS","Foundation for the National Institutes of Health","NIMH NIH HHS","NHLBI NIH HHS","Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)","NINDS NIH HHS"],"pagination":["956"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11754601"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Microglia and the border-associated macrophages contribute to the modulation of cerebral blood flow, but the mechanisms have remained uncertain. Here, we show that microglia regulate the cerebral blood flow baseline and the responses to whisker stimulation or intra-cisternal magna injection of adenosine triphosphate, but not intra-cisternal magna injection of adenosine in mice model. Notably, microglia repopulation corrects these cerebral blood flow anomalies. The microglial-dependent regulation of cerebral blood flow requires the adenosine triphosphate-sensing P2RY12 receptor and ectonucleotidase CD39 that initiates the dephosphorylation of extracellular adenosine triphosphate into adenosine in both male and female mice. Pharmacological inhibition or CX3CR1-CreER-mediated deletion of CD39"],"journal":["Nature communications"],"pubmed_title":["Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39."],"pmcid":["PMC11754601"],"funding_grant_id":["RF1 AG068558","R01 MH118329","951515","NS127392","R21 HD109025","R01 NS135693","F31 AG074652","R01 NS125677","R01 NS125788","R21 NS127392","R01 HL094400","R01 AG072489","P01 DA047233","R21 AG065923","R01 NS121014","R01 NS108763","NS125677","R01 NS106721","R01 HL167511","R01 AG068558","NS125788"],"pubmed_authors":["Hwang P","Chen HR","Fu Z","Eyo UB","Quintana FJ","Pridans C","Weybright A","Bian E","Kumar P","Sun YY","Kinkaid MM","Tan X","Ganesana M","Venton BJ","Sol-Church K","Schaefer A","Kuan CY","Robson SC"],"additional_accession":[]},"is_claimable":false,"name":"Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39.","description":"Microglia and the border-associated macrophages contribute to the modulation of cerebral blood flow, but the mechanisms have remained uncertain. Here, we show that microglia regulate the cerebral blood flow baseline and the responses to whisker stimulation or intra-cisternal magna injection of adenosine triphosphate, but not intra-cisternal magna injection of adenosine in mice model. Notably, microglia repopulation corrects these cerebral blood flow anomalies. The microglial-dependent regulation of cerebral blood flow requires the adenosine triphosphate-sensing P2RY12 receptor and ectonucleotidase CD39 that initiates the dephosphorylation of extracellular adenosine triphosphate into adenosine in both male and female mice. Pharmacological inhibition or CX3CR1-CreER-mediated deletion of CD39","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-01T18:06:09.237Z","creation":"2025-04-04T22:07:02.895Z"},"accession":"S-EPMC11754601","cross_references":{"pubmed":["39843911"],"doi":["10.1038/s41467-025-56093-5"]}}