{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li D"],"funding":["National Natural Science Foundation of China"],"pagination":["17"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11756136"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background</h4>Lung cancer, particularly non-small cell lung cancer (NSCLC), has high recurrence rates and remains a leading cause of cancer-related death, despite recent advances in its treatment. Emerging therapies, such as chimeric antigen receptor (CAR)-T cell therapy, have shown promise but face significant challenges in targeting solid tumors. This study investigated the potential of combining receptor tyrosine kinase-like orphan receptor 1 (ROR1)-targeting CAR-T cells with ferroptosis inducers to promote ferroptosis of tumor cells and enhance anti-tumor efficacy.<h4>Methods</h4>RNA-seq data and immunofluorescence analysis of relapsed NSCLC patient samples were used to explore ROR1 expression. In addition, ROR1-targeting CAR-T cells were developed to assess cytotoxic activity aga"],"journal":["Biomarker research"],"pubmed_title":["ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2."],"pmcid":["PMC11756136"],"funding_grant_id":["82200245, 82104447, 82302641"],"pubmed_authors":["Liu H","Ma L","Li D","Guo W","Shan L","Lu C","Hou X","Wang J","Xie S","Zhang W","Wang R","Huang Z","Wang Y","Xu Z"],"additional_accession":[]},"is_claimable":false,"name":"ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2.","description":"<h4>Background</h4>Lung cancer, particularly non-small cell lung cancer (NSCLC), has high recurrence rates and remains a leading cause of cancer-related death, despite recent advances in its treatment. Emerging therapies, such as chimeric antigen receptor (CAR)-T cell therapy, have shown promise but face significant challenges in targeting solid tumors. This study investigated the potential of combining receptor tyrosine kinase-like orphan receptor 1 (ROR1)-targeting CAR-T cells with ferroptosis inducers to promote ferroptosis of tumor cells and enhance anti-tumor efficacy.<h4>Methods</h4>RNA-seq data and immunofluorescence analysis of relapsed NSCLC patient samples were used to explore ROR1 expression. In addition, ROR1-targeting CAR-T cells were developed to assess cytotoxic activity aga","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-02T07:11:17.008Z","creation":"2025-04-05T00:25:37.376Z"},"accession":"S-EPMC11756136","cross_references":{"pubmed":["39849645"],"doi":["10.1186/s40364-025-00730-0"]}}