biostudies-literatureJiang QZhejiang Science and Technology Major Program on Agricultural New Variety Breeding–Tea PlantNational Natural Science Foundation of ChinaElite Youth Program of Chinese Academy of Agricultural SciencesCentral Public-interest Scientific Institution Basal Research Funduhae281https://www.ebi.ac.uk/biostudies/studies/S-EPMC11756293biostudies-literatureUnknown12(1)Leucine-rich repeat receptor-like kinases (LRR-RLKs) have emerged as key regulators of herbivory perception and subsequent defense initiation. While their functions in grass plants have been gradually elucidated, the roles of herbivory-related LRR-RLKs in woody plants remain largely unknown. In this study, we mined the genomic and transcriptomic data of tea plants (<i>Camellia sinensis</i>) and identified a total of 307 CsLRR-RLK members. Phylogenetic analysis grouped these CsLRR-RLKs into 14 subgroups along with their Arabidopsis homologs. Gene structure and conserved domain analyses revealed notable similarities among subgroup members. Among the identified CsLRR-RLKs, we focused on two plasma membrane-localized LRR-RLKs, CsLRR-RLK44, and CsLRR-RLK239, which do not form homodimers or heteHorticulture researchTwo leucine-rich repeat receptor-like kinases initiate herbivory defense responses in tea plants.PMC117562932021C02067Y2023PT0332372775Ye MWu ZLiu YFeng LDing CHuang JJiang QZeng JHe LLiu CWang LfalseTwo leucine-rich repeat receptor-like kinases initiate herbivory defense responses in tea plants.Leucine-rich repeat receptor-like kinases (LRR-RLKs) have emerged as key regulators of herbivory perception and subsequent defense initiation. While their functions in grass plants have been gradually elucidated, the roles of herbivory-related LRR-RLKs in woody plants remain largely unknown. In this study, we mined the genomic and transcriptomic data of tea plants (<i>Camellia sinensis</i>) and identified a total of 307 CsLRR-RLK members. Phylogenetic analysis grouped these CsLRR-RLKs into 14 subgroups along with their Arabidopsis homologs. Gene structure and conserved domain analyses revealed notable similarities among subgroup members. Among the identified CsLRR-RLKs, we focused on two plasma membrane-localized LRR-RLKs, CsLRR-RLK44, and CsLRR-RLK239, which do not form homodimers or hete2025-01-01T00:00:00Z2025 Jan2026-04-18T03:24:50.425Z2025-04-19T18:23:52.34ZS-EPMC117562933985037110.1093/hr/uhae281