biostudies-literatureUnknown6(1)Zala M<h4>Background</h4>The normal values of the complete blood count are part of the foundational medical knowledge that is seldom questioned due to their well-established nature. These normal values are critical for optimal physiological function while minimizing the harmful consequences of an excessive number of blood cells. Thus, they represent an evolutionary trade-off likely shaped by natural selection if they significantly influence individual fitness and exhibit heritability.<h4>Methods</h4>On the basis of the analysis of normal blood count values of 94 mammalian species, we discovered that certain parameters are strongly associated with diet, habitat, and lifespan.<h4>Results</h4>Carnivorous mammals had higher hemoglobin levels than vegetarians, and aquatic mammals displayed red blood EJHaeme1073https://www.ebi.ac.uk/biostudies/studies/S-EPMC11756989biostudies-literatureWhat is the origin of the normal ranges of blood cell counts? An evolutionary perspective.PMC11756989Alcazer VZala MSujobert PLargeaud LfalseWhat is the origin of the normal ranges of blood cell counts? An evolutionary perspective.<h4>Background</h4>The normal values of the complete blood count are part of the foundational medical knowledge that is seldom questioned due to their well-established nature. These normal values are critical for optimal physiological function while minimizing the harmful consequences of an excessive number of blood cells. Thus, they represent an evolutionary trade-off likely shaped by natural selection if they significantly influence individual fitness and exhibit heritability.<h4>Methods</h4>On the basis of the analysis of normal blood count values of 94 mammalian species, we discovered that certain parameters are strongly associated with diet, habitat, and lifespan.<h4>Results</h4>Carnivorous mammals had higher hemoglobin levels than vegetarians, and aquatic mammals displayed red blood 2025-01-01T00:00:00Z2025 Feb2025-04-18T12:47:14.413Z2025-04-06T22:08:25.158ZS-EPMC117569893986694010.1002/jha2.1073