biostudies-literatureUnknown39(1)Wang WAustralian Companion Animal Health Foundation<h4>Background</h4>Altered gut microbiota has been associated with dopaminergic degenerative diseases in people, but studies on horses with pituitary pars intermedia dysfunction (PPID) are lacking.<h4>Hypothesis/objectives</h4>Investigate the effect of PPID on fecal microbiota in horses.<h4>Animals</h4>Nine horses with PPID and 13 age-matched control horses.<h4>Methods</h4>Prospective control study. Fecal samples were collected bimonthly. Microbial analysis used 16S rRNA sequencing to determine the relative abundance at genus and phylum levels, assess alpha and beta diversity and identify core microbiota.<h4>Results</h4>Horses with PPID had decreased relative abundances of Christensenellaceae R-7 group (median; 95% confidence interval [CI]: PPID, 2.04; 1.82-2.35 vs control, 2.54; 2.37-2.76Journal of veterinary internal medicinee17288https://www.ebi.ac.uk/biostudies/studies/S-EPMC11758151biostudies-literatureCharacterization and comparison of fecal microbiota in horses with pituitary pars intermedia dysfunction and age-matched controls.PMC11758151Horsman SGibson JWang WMikkelsen DBertin FRfalseCharacterization and comparison of fecal microbiota in horses with pituitary pars intermedia dysfunction and age-matched controls.<h4>Background</h4>Altered gut microbiota has been associated with dopaminergic degenerative diseases in people, but studies on horses with pituitary pars intermedia dysfunction (PPID) are lacking.<h4>Hypothesis/objectives</h4>Investigate the effect of PPID on fecal microbiota in horses.<h4>Animals</h4>Nine horses with PPID and 13 age-matched control horses.<h4>Methods</h4>Prospective control study. Fecal samples were collected bimonthly. Microbial analysis used 16S rRNA sequencing to determine the relative abundance at genus and phylum levels, assess alpha and beta diversity and identify core microbiota.<h4>Results</h4>Horses with PPID had decreased relative abundances of Christensenellaceae R-7 group (median; 95% confidence interval [CI]: PPID, 2.04; 1.82-2.35 vs control, 2.54; 2.37-2.762025-01-01T00:00:00Z2025 Jan-Feb2025-04-19T18:23:53.268Z2025-04-19T18:23:53.268ZS-EPMC117581513985382510.1111/jvim.17288